摘要
目的建立基于上午一次性随机尿与24小时尿肌酐校正的孕妇人群碘营养水平的评估方法。方法 2016年3—10月在北京协和医院妇产科门诊,依照研究方案拟定的纳入排除标准招募健康孕妇116名,收集上午8:00-11:30期间的一次性随机尿与其后24小时尿,并测定随机尿与24小时尿碘浓度(UIC)、尿肌酐含量(UCr);然后,将随机尿碘/肌酐比值(UIC/Cr)乘以24小时尿肌酐排出量(24-h UCr E)估算孕妇人群24小时尿碘排出量(24-h UIE)。结果孕妇人群上午一次性随机尿与24小时尿UIC、UIC/Cr等指标间差异有统计学意义(P<0.05),且随机尿UIC、UIC/Cr、24-h UIE估计值与24-h UIE实测值之间均显著相关(P<0.05),妊娠期孕妇人群24-h UIE估计值均相当于24-h UIE实测值的70%~80%水平。结论妊娠期孕妇上午一次性随机尿不能直接替代24小时尿用于评估碘营养水平,而基于随机尿UIC/Cr与24-h UCr E的方法可为评估妊娠期孕妇人群近期碘营养状况提供技术参考。
Objective To establish a reliable method of iodine nutritional assessment for pregnant women using the adjusted urinary creatinine of spot urine and 24-hour urine samples.Methods The spot urine in the morning at 8 00-11：30 and the following 24-hour urine samples of pregnant women were collected in Peking Union Medical College Hospital during March to October in 2016.The urinary iodine and urinary creatinine concentrations were determined.The estimated 24-hour urinary iodine excretion（ 24-h UIE） was calculated using the urinary iodine/urinary creatinine（ UIC/Cr） ratio of spot urine,and 24-hour urinary creatinine excretion（ 24-h UCr E）.Results There was a significant difference in the UIC,UIC/Cr ratio between spot urine and 24-h urine（ P 〈0.05）.The UIC,UIC/Cr ratio of spot urine,and the estimated 24-h UIE all were significantly correlated with the real 24-h UIE（ P 〈 0.01）,especially the estimated 24-h UIE were taking up 70%-80% for the real 24-h UIE in the period of gestation.Conclusion The UIC,UIC/Cr,and the estimated 24-h UIE cannot directly replace the relevant values derived of the 24-hour urine samples.But the estimated 24-h UIE can reflect the iodine nutritional status of pregnant women in recent days,and the method could be a reliable reference for the iodine nutritional assessment of the pregnant women in practice.
作者
刘小兵
武萌
张宇
卢佳希
朴建华
杨丽琛
杨晓光
Liu Xiaobing;Wu Meng;Zhang Yu;Lu Jiaxi;Piao Jianhua;Yang Lichen;Yang Xiaoguang(Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission,National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China)
出处
《卫生研究》
CAS
CSCD
北大核心
2018年第4期548-553,共6页
Journal of Hygiene Research
基金
中国疾病预防控制中心营养与健康所青年科学基金(No.NINH2016001)
关键词
孕妇
碘营养水平
尿碘
尿肌酐
pregnant women
iodine nutrition
urinary iodine
urinary creatinine
