摘要
目的探讨二羟丙茶碱全麻诱导前对肺灌洗液中的IL-8(白细胞介素-8)、ICAM-1(中性粒细胞黏附因子-1)的影响。方法选取我院行上腹部手术气管内全麻200例患者为研究对象,分为对照组与喘定组,每组100例。予以对照组生理盐水,予以喘定组二羟丙茶碱麻醉诱导前静注。结果在手术结束时、气管拔除前,对照组的肺灌洗液中IL-8和ICAM-1表达显著高于喘定组(P <0. 05);相比静脉开放半小时时段,对照组与喘定组患者Pa O2水平在开放后2 h时段呈上升趋势,且对照组患者的上升幅度高于喘定组(P <0. 05);相比开放后2 h时段,对照组与喘定组患者Pa O2水平在开放后6 h均呈降低趋势,但对照组降低幅度显然无喘定组降低明显(P <0. 05)。结论行全麻前实施二羟丙茶碱预处理,能有效提升抗炎作用,而且还能维持血气指标稳定及降低IL-8、ICAM-1在肺灌洗液中的表达水平。
Objective To explore the influences of diprophylline on IL-8 （interleukin-8） and ICAM-1 （neutral granulocyte adhesion factor-1 ） in lung lavage fluid before general anesthesia. Methods A total of 200 patients who underwent the operation of trachea general anesthesia in the First Affiliated Hospital of Jiamusi University were recruited, with 100 cases in setting and control group respectively. Before general anesthesia, the diprophylline intravenous injection were given in the setting group and normal saline were given in the control group. Results At the end of the operation but before the removal of the trachea, the expression of IL-8 and ICAM-1 in lung lavage fluid was significantly higher in the control group than that in the setting group （ P 〈 0. 05 ） ; The PaO2 level increased significantly higher in 2 h than that in half an hour after intravenous injection in both the setting and control group, with significantly higher increase in control group than in setting group （ P 〈 0.05 ）. The PaO2 level decreased signifi- cantly in 6 h compared with 2 h after intravenous injection in both setting group and control group, with significantly more decrease in setting group than in control group （P 〈 0. 05 ）.Conclusion The diprophylline pretreatment before the general anesthesia not only can en- hance the anti-inflammatory effect effectively, but also can maintain a stable blood gas index and reduce the expression levels of IL-8 and ICAM-1 in lung lavage fluid as well.
作者
刘海萍
国麟祺
王东伟
曾凡荣
郭红
LIU Hai-ping;GUO Lin-qi;WANG Dong-wei;ZENG Fan-rong;GUO Hong(Department of Anesthesiology,The First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China)
出处
《哈尔滨医科大学学报》
CAS
2018年第2期129-131,共3页
Journal of Harbin Medical University
基金
黑龙江省卫生计生委科研课题(2017-391)
关键词
肺灌洗液
全麻诱导
二羟丙茶碱
lung lavage fluid
general anesthesia induction
diprophylline
