摘要
目的探讨鼠神经因子联合前列地尔治疗糖尿病周围神经病变的治疗效果。方法 78例糖尿病周围神经病变患者,随机分成治疗组(40例)和对照组(38例)。治疗组采用鼠神经生长因子联合前列地尔治疗,对照组采用甲钴胺和前列地尔治疗。两组均严格控制血糖和饮食,治疗14 d。对比治疗前后两组患者指标变化情况及疗效。结果治疗后,两组患者腓总神经、正中神经的感觉神经传导速度(SNCV)和运动神经传导速度(MNCV)均优于治疗前,且治疗组优于对照组,差异有统计学意义(P<0.05);治疗后,两组患者多伦多临床神经病变评分(TCSS评分)优于治疗前,且治疗组优于对照组,差异有统计学意义(P<0.05);治疗组总有效率为82.5%,高于对照组的63.2%,差异有统计学意义(P<0.05)。结论鼠神经生长因子联合前列地尔能有效治疗糖尿病周围神经病变。
Objective To investigate the treatment effect of the nerve growth factor of mice combined with Alprostadil in the treatment of diabetic peripheral neuropathy.Methods A total of 78 patients with diabetic peripheral neuropathy were randomly divided into the treatment group for 40 cases and the control group for 38 cases.The treatment group was given nerve growth factor of mice combined with Alprostadil,and the control group was given Cobalamin and Alprostadil.The two groups were strictly controlled blood glucose and diet,treatment for 14 days,the change of indicators before and after treatment,the curative effect between the two groups were compared.Results After treatment,the sensory nerve conduction velocity（SNCV） and motor nerve conduction velocity（MNCV） of the common peroneal nerve and median nerve in both groups were significantly better than before treatment,and above indicators of treatment group were significantly better than the control group,the differences were statistically significant（P〈0. 05）.After treatment,the Toronto clinical scoring system（TCSS） of the two groups were significantly better than before treatment,and that of treatment group was significantly better than control group,the difference were statistically significant（P〈0. 05）.The total effective rate of treatment group was 82.5%,which was significantly higher than 63.2% of control group,the difference was statistically significant（P〈0. 05）.Conclusion The nerve growth factor of mice combined with Alprostadil can effectively treat diabetic peripheral neuropathy.
作者
邵志坚
SHAO Zhi-jian(Sihui City Hospital of Traditional Chinese Medicine,Sihui 526200,Chin)
出处
《中国实用医药》
2018年第20期6-8,共3页
China Practical Medicine
关键词
鼠神经生长因子
前列地尔
糖尿病周围神经病变
疗效分析
Nerve growth factor of mouse
Alprostadil
Diabetic peripheral neuropathy
Curative effect analysis
