摘要
目的分析山西地区感染性眼病分离的表皮葡萄球菌的临床感染特点及其耐药情况，以指导-临床用药。方法收集感染性眼病患者所送检的各类标本中分离出表皮葡萄球菌114株，采用法国生物梅里埃VITEK Compact2全自动细菌鉴定药敏分析仪鉴定细菌类别及抗茵药物敏感性，并用纸片扩散法（K—B法）对药敏试验进行补充。结果感染性眼病以眼外伤为主，并以中青年男性为主要人群。标本主要取自结膜囊分泌物，占71．05％。114株表皮葡萄球菌中MRSE阳性率为70．18％，表皮葡萄球菌对多种抗菌药物耐药，未发现对替加环素、利奈唑胺、万古霉素、喹努普汀／达福普汀有耐药的菌株。结论感染性眼病中分离的表皮葡萄球菌对多种常用抗菌药物不敏感，具有多重耐药性，耐药形势很严峻，应重视加强表皮葡萄球菌耐药性的检测，为临床医师和实验人员提供指导，并根据药敏结果规范合理使用抗生素。
Objective To analyze the clinical infection characteristics and drug resistance of Staphylococcus epidermidis isolated from infectious ocular diseases in Shanxi Province, so as to guide clinical medication. Methods One hundred and fourteen strains of Staphylococcus epidermidis isolated from specimens of patients with infectious eye diseases. The bacterial classification and antimicrobial sus- ceptibility were identified by the French Biornerieux VITEK Compact2 automatic bacterial identification susceptibility analyzer, and the drug sensitivity test was supplemented by the paper diffusion （K-B） method. Results The infectious eye disease mainly was ocular trauma, with young and middle-aged men as main group. The specimens were mainly from conjunctival sac secretions, accounting for 71.05%. The positive rate of Methicillin-resistant Staphylococcus epidermidis in 114 strains of staphylococcus epi- dermidis was 70. 18% , Staphylococcus epidermidis resistant to a variety of antimicrobials, without tigecy- cline, linezolid, vancomycin, quinupritin/dalfopristin. Conclusions Staphylococcus epidermidis isola- ted from infectious ophthalmopathy is not sensitive to a variety of commonly used antibiotics, with multi- ple drug resistance. Drug resistance of Staphylococcus epidermidis is very serious, so it is necessary to pay attention to strengthen the detection of Staphylococcus epidermidis drug resistance, provide guidance for clinicians and laboratory personnel, and rational use antibiotics based on drug susceptibility results.
作者
张云琴
康玉国
赵海莉
Zhang Yunqin;Kang Yuguo;Zhao Haili(Department of Laboratory,Shanxi Eye Hospital,Taiyuan 030002,Chin)
出处
《中国实用医刊》
2018年第13期21-22,25,共3页
Chinese Journal of Practical Medicine
关键词
表皮葡萄球菌
耐药性
感染性眼病
Staphylococcus epidermidis
Resistance
Infectious eye disease
