摘要
Background and Objectives： the effects of oral enteral nutrition （EN） in lung cancer patients receivingchemotherapy and/or radiotherapy were controversial, so we made a systematic review to analyze the clinicalefficacy of EN in lung cancer patients after chemotherapy and/or radiotherapy. Methods and Study Design：Pertinent studies were identified by searching in PubMed, Embase, Web of Science, Cochrane Library, ChinaNational Knowledge Infrastructure （CNKI）, WanFang Database, China Biomedical Literature database （CBM） andChinese Science and Technology Periodical Database （VIP）. Energy intake, protein intake, weight and other datawere extracted. Results： Finally, 5 randomized controlled trials （RCTs） were included in this systematic review.Patients in 3 studies received chemotherapy, in 1 with radiotherapy and in 1 with chemo-radiotherapy. Thecombined results showed that EN significantly increased energy and protein intake in lung cancer duringchemotherapy, while there was no significant effect on other results after patients had received chemotherapyand/or radiotherapy. Conclusions： Limited evidence is available to judge whether EN can improve clinical effect oflung cancer with or without chemotherapy and/or radiotherapy, as clinical heterogeneity and other potentialvariation existed in this review. Further studies are needed.
目的：系统评价口服肠内营养支持对接受放化疗的肺癌患者的临床疗效与可行性.方法：计算机检索相关主要中英文数据库,并手工检索相关营养学杂志.采用The Cochrane Colla boration’stool for assessingrisk of bias5.1.0进行质量评价,RevMan5.1软件进行统计分析.由于纳入的研究之间有明显的临床异质性和其他潜在的差异,不适合行meta分析,因此行简要定性分析更加合适.结果：最终纳入5个随机对照试验（RCT）,其中3个RCT研究对象接受化疗,1个RCT研究对象接受放疗,1个RCT研究对象接受放疗及化疗.综合的分析结果提示口服肠内营养仅能够显著提高接受化疗肺癌患者的能量和蛋白质摄入量,然而对于体重、营养状态、生存质量、治疗反应或者生存时间没有显著影响.结论：现有的证据不足以证明常规口服肠内营养支持能使接受放化疗的肺癌患者获益,由于样本量少,各研究之间差异大,更多高质量的随机对照试验有待进行.
基金
Funding：This research was supported by NSFC （Natural Science Foundation of China） （81360351, 81660512）,the Department of Science and Technology of Guizhou Province （Grant No. Qian Ke He SY [2013] 3003）,High-level Innovative Talents Cultivation Program Of Guizhou Province, Start-Up Fund for Doctor of ZunyiMedical University and the Social Practice Program for Postgraduate of Zunyi Medical University（Grant No.zy-yjs2015004）, Applied Basic Research Programs of Science and Technology Commission Foundation of SichuanProvince （Grant No. 2012JY0058）
