摘要
目的:探析胺碘酮治疗心律失常的效果及对患者心率变异性(Heart rate variability,HRV)、血清炎症因子水平的影响。方法:选取2016年11月-2017年12月本院收治的心律失常患者96例。按照随机数字表法将其分为观察组和对照组,各48例。对照组给予普罗帕酮治疗,观察组给予胺碘酮治疗,均持续治疗4周。比较两组治疗前后的HRV参数(r MSSD、SDNN、s DNNindex)、血清炎症因子水平(IL-6、hs-CRP、TNF-α),以及临床疗效及不良反应。结果:观察组治疗总有效率为91.67%,明显高于对照组的72.92%(X^2=5.790,P=0.016);治疗后,两组r MSSD、SDNN、sDNNindex均高于治疗前,且观察组均高于对照组,比较差异均有统计学意义(P<0.05);治疗后,两组IL-6、hs-CRP、TNF-α水平均低于治疗前,且观察组均低于对照组,比较差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胺碘酮治疗心律失常效果显著,可有效改善患者HRV参数异常,减轻炎症反应,安全可靠,具有较高的推广价值。
Objective：To investigate the effect of Amiodarone on arrhythmia and its effect on heart rate variability（HRV） and serum levels of inflammatory factors.Method：A total of 96 patients with arrhythmia admitted to our hospital from November 2016 to December 2017 were selected.According to the random number table,they were divided into observation group and control group,48 cases in each group.Control group was given Propafenone treatment,and observation group was given Amiodarone treatment,they were treated continuously for 4 weeks.The HRV parameters（r MSSD,SDNN,s DNNindex） and serum inflammatory factors（IL-6,hs-CRP,TNF-α） before and after treatment,clinical efficacy,adverse reactions between two groups were compared.Result：The total effective rate of observation group was 91.67%,which was significantly higher than 72.92% of control group（ X^2=5.790,P=0.016）.After treatment,the r MSSD,SDNN,s DNNindex in two groups were higher than before treatment,and observation group were higher than those of control group,the differences were statistically significant（P〈0.05）.After treatment,the serum levels of IL-6,hs-CRP and TNF-α in two groups were lower than those before treatment,and observation group were lower than those of control group,the differences were statistically significant（P〈0.05）.The incidence of adverse reactions in two groups was compared,the difference was not statistically significant（P〉0.05）.Conclusion：Amiodarone is effective in treating arrhythmia,which can effectively improve the abnormality of HRV parameters,relieve the inflammatory reaction,be safe and reliable,and have high popularization value.
作者
潘丽
PAN Li(Jiamusi Maternal and Child Health Care Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2018年第17期99-102,共4页
Medical Innovation of China
关键词
胺碘酮
心律失常
心率变异
炎症反应
Amiodarone
Arrhythmia
Heart rate variability
Inflammatory reaction
