摘要
目的:观察补肾活血方联合西医治疗老年2型糖尿病合并骨质疏松症患者的临床疗效,及其对患者骨代谢标志物、骨密度的影响。方法:200例老年2型糖尿病合并骨质疏松症患者按照数字表法随机分为观察组和对照组各100例。对照组给予常规西医治疗,观察组在对照组治疗基础上给予补肾活血方。24周后比较两组患者临床疗效、骨密度(bone mineral density,BMD)、T值[T值=(受检者BMD值-青年人BMD均值)/青年人BMD标准差]、β胶原特殊序列、总骨Ⅰ型前胶原N端肽(aminoterminal prepeptide typeⅠprocollagen,PⅠNP)、骨钙素、血钙、血磷、血碱性磷酸酶(alkaline phosphatase,ALP)水平。结果:观察组有效率为96.00%,对照组为75.00%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗前BMD和T值比较,差异均无统计学意义(P>0.05);观察组治疗后BMD、T值均显著高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组β胶原特殊序列、骨钙素水平明显低于对照组(P<0.01),观察组血清PINP水平明显高于对照组(P<0.01)。两组患者血钙、血磷和血ALP治疗前后比较,差异均无统计学意义(P>0.05)。结论:补肾活血方治疗老年2型糖尿病合并骨质疏松症临床疗效显著,可有效改善患者骨代谢和骨密度。
Objective：To observe the clinical efficacy of Bushen Huoxue Prescription combined with western medicine in the treatment of elderly patients with type 2 diabetes with osteoporosis,and the effect on bone metabolism markers and bone mineral density（BMD）. Methods：200 patients with diabetes were randomly divided into the observation group and the control group with each group 100 cases. The patients in the control group were treated by conventional western medicine treatment,while patients in the observation group were treated by Bushen Huoxue Prescription on the basis of the conventional treatment. After 24 weeks,the clinical efficacy of the two groups were compared. The results of BMD,T value,Serum levels of β-Crosslaps,aminoterminal prepeptide type Ⅰ procollagen（ PⅠNP）,osteocalcin,blood calcium,blood phosphorus,and serum alkaline phosphatase（ ALP） were compared between the two groups. Results：The clinical effective rate was 96. 00% in the observation group,which were significantly higher than that in the control group 75. 00%（ P〈0. 05）. Results of BMD and T value showed that in the observation group were all much higher than that in the control group,and the difference was statistically significant（ P〈0. 05）. The serum levels of β-Cross-laps and N-MIN osteocalcin were significantly lower in the observation group than those in the control group（ P〈0. 01）,while the serum levels of PINP in the observation group were significantly higher than those in the control group（ P〈0. 01）. Results of calcium,phosphorus and blood ALP showed no significant difference. There was no statistically significant difference（ P〈0. 05）. Conclusion：Bushen Huoxue Prescription combined western medicine treatment shows better effect in the treatment of bone metabolism in diabetic osteoporosis patients. It is effective to increase bone metabolism and bone mineral density in gerontism type 2 diabetic osteoporosis patients.
作者
刘菊
梅群超
张林英
龚星星
LIU Ju;MEI Qunchao;ZHANG Linying;GONG Xingxing(The Hospital of Integrative Medicine,Tongji Medical College,Huazhong University of Science and Technology/The First Hospital of Wuhan,Wuhan Hubei China 43002)
出处
《中医学报》
CAS
2018年第7期1226-1229,共4页
Acta Chinese Medicine
基金
湖北省武汉市卫生和计划生育委员会资助项目(WZ14Z09)
关键词
补肾活血方
糖尿病合并骨质疏松症
骨密度
骨代谢标志物
中西医结合
Bushen Huoxue Prescription
diabetes mellitus with osteoporosis
bone mineral density
bone metabolism markers
Inte-grative medicine
