摘要
创伤后应激障碍(post-traumatic stress disorder,PTSD)是人体遭遇重大创伤后,出现睡眠障碍、焦虑、恐惧以及认知障碍等症状的一种严重精神障碍。在过去几十年中,国内外已建立了多种的啮齿动物压力模型,用于研究PTSD潜在的病理生理学机制。模型动物会出现类似PTSD的症状,但每种动物模型都不能完整表现出PTSD所有的症状以及生物学变化。因此本文就近几年常用的PTSD模型的造模方法、生理学改变等做出简要的概述总结。
Post-traumatic stress disorder（ PTSD） is a serious psychiatric disorder when someone suffered from a major trauma,next followed by sleep disorder,emotional and cognitive disorder and other symptoms. Over the past few decades,many stress rodents models have been developed for searching the potential pathophysiological pathways of PTSD.All models showed PTSD-like symptoms,but none of them could manifestate all the symptoms and biological changes of PTSD completely. Thus,this article makes a brief summary about the PTSD models commonly used in recent years.
作者
王畅
邵水金
刘玉璞
朱晶
WANG Chang, SHAO Shuijin, LIU Yupu, ZHU Jing(Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, Chin)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2018年第3期404-409,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金青年科学基金项目(No.81704158)
上海市科学技术委员会"杨帆计划"(No.17YF1419600)
中国博士后科学基金面上项目(No.2017M611610)
上海市中医药大学预算内项目(No.2016YSN03)~~
