摘要
目的探讨妊娠期亚临床甲状腺功能减退症(SCH)对妊娠结局的影响。方法选择2015年6月~2017年6月我院收治的妊娠合并SCH的患者90例作为观察组,另选择同期在我院产检的健康妊娠产妇95例作为对照组。分别采集两组的血清样本,按照化学发光免疫分析法,检测血清中血清游离甲状腺素(FT_4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAB)的含量,并给予相应的治疗。结果观察组妊娠期高血压、胎膜早破、产后出血、贫血的发生率显著高于对照组,差异有统计学意义(P<0.05)。两组妊娠期糖尿病、肝内胆汁淤积症、流产、低蛋白血症的发生率比较,差异无统计学意义(P>0.05)。观察组胎儿宫内窘迫、胎儿宫内生长受限的发生率明显高于对照组,差异有统计学意义(P<0.05)。两组低出生体重儿、胎儿畸形、新生儿窒息的发生率比较,差异无统计学意义(P>0.05)。结论妊娠合并亚临床甲减对妊娠结局有明显不良影响,需要进行相应的临床干预,以减少不良妊娠结果。
Objective To investigate the effect of subclinical hypothyroidism during pregnancy on pregnancy outcome.Methods Ninety cases of pregnancy with subclinical hypothyroidism（SCH） in our hospital from June 2015 to June 2017 were selected as the observation group.At the same time,95 cases of healthy pregnant women were selected as the control group.Two groups of maternal serum samples were collected respectively.Serum free thyroxine（FT_4）,thyroid stimulating hormone（TSH） and thyroid peroxidase antibody（TPOAB） levels in serum were detected by chemiluminescence immunoassay.And give the corresponding treatment.Results The incidence of pregnancy induced hypertension,premature rupture of membranes,postpartum hemorrhage and anemia in the observation group was significantly higher than that in the control group,the differences were statistically significant（P〈0.05）.There were no significant difference in the incidence of gestational diabetes,intrahepatic cholestasis,abortion,and hypoproteinemia in the two groups（P〉0.05）.The incidence of fetal intrauterine distress and fetal intrauterine growth restriction in the observation group was significantly higher than that in the control group,with a significant difference（P〈0.05）.There were no significant difference in the incidence of low birth weight infants,fetal malformation and neonatal asphyxia in the two groups（P〉0.05）.Conclusion Subclinical hypothyroidism of pregnancy has an obvious adverse effect on pregnancy outcome,and corresponding clinical intervention should be carried out to reduce the result of bad pregnancy.
作者
李晓玲
邓姗
邓清华
LI Xiao-ling;DENG Shan;DENG Qing-hua(Department of Obstetrics,the Second People＇s Hospital of Zhanjiang City,Guangdong Province,Zhanjiang 524000,Chai)
出处
《中国当代医药》
2018年第17期107-109,共3页
China Modern Medicine
