摘要
目的:探讨膦甲酸钠对带状疱疹患者的临床应用价值。方法:选择2015年10月—2017年12月在我院治疗的带状疱疹患者102例,将所有患者随机分为2组,每组各51例。对照组采用阿昔洛韦治疗,观察组采用膦甲酸钠治疗,比较2组恢复效果、T淋巴细胞亚群水平、不良反应发生情况。结果:观察组止痛时间、止疱时间、结痂时间以及痊愈时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组CD3+、CD4+、CD4+/CD8+水平均高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05);观察组神经疼痛评分低于对照组,差异有统计学意义(P<0.05);2组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论:采用膦甲酸钠治疗带状疱疹患者,可有效缩短止痛、止疱、结痂等时间,缓解神经疼痛,利于调节T淋巴细胞亚群水平,进而促使病情早日转归。
Objective： To explore the application value of phosphonoformic acid in patients with herpes zoster. Methods： 102 patients with herpes zoster treated in our hospital from Oct 2015 to Dec 2017 were random Ly divided into 2 group and with 51 patients in each group. The control group was treated with acyclovir, and the observation group was treated with sodium formate, and the effect of two groups, the level oftlymphocyte subgroup and the occurrence of adverse reaction were compared. Results： The analgesic time, time, time and recovery time of the observation group were shorter than those in the control group. The levels of CD3＋, CD4＋ and CD4＋/CD8＋ were higher than those in the control group, and the level of CD8＋ was lower than that of the control group. The scores of neuralgia were lower than those in the control group, the difference was statistically significant（P〈0.05）.Conclusion： The use of phosphonoformate in patients with herpes zoster can effectively reduce the time of pain stop, stop blister and scab, relieve nerve pain and adjust the level oftlymphocyte subgroup, and promote the prognosis of the disease as soon as possible.
作者
田分
TIAN Fen(Dermatology ＆ STD Department,Zhengzhou No.6 people＇s Hospital,Zhengzhou Henan 450015,China)
出处
《药品评价》
CAS
2018年第12期55-57,61,共4页
Drug Evaluation
关键词
带状疱疹
膦甲酸钠
阿昔洛韦
Herpes Zoster
Phosphonoformic Acid Sodium
Acyclovir
