摘要
测算鸡与其他实验动物等效剂量换算系数,为完善鸡常用基础实验数据提供依据。用Photoshopcc 2015测算鸡皮表面积,基于体质量与体表面积,求出鸡在Meeh-Rubner氏公式中的K值,计算出鸡与其他实验动物之间药物剂量换算的系数。鸡在Meeh-Rubner氏公式中的K值为9.24±1.03,mg/kg^mg/m^2转移因子为10.00±1.36,单位体重上表面积的相对比值为0.30±0.044。研究结果可为鸡在生物医学及畜牧养殖方面的健康合理用药提供重要信息。
The purpose of this paper was to calculate the equivalent dose conversion coefficients of chickens and other experimental animals to provide evidence for the improvement of basic experimental data in chickens.Photoshopcc 2015 was used to measure the skin surface area of chickens.Based on body weight and body surface area,we can get chicken K value from the Meeh-Rubner＇s formula,so as to calculate the drug dose conversion coefficient between chickens and other experimental animals.The K value calculated from chicken Meeh-Rubner＇s formula was 9.24±1.03,mg/kg-mg/m2 transfer factor was 10.00±1.36,and unit of surface area and the body weight ratio was 0.30±0.44.This study provided important information for rational drug use in bio-medical and husbandry aspects of applications.
作者
李紫元
刘逸雷
梁伟燊
刘俊丹
邱文才
唐陆平
何永明
LI Zi-yuan;LIU Yi-lei;LIANG Wei-shen;LIU Jun-dan;QIU Wen-cai;TANG Lu-ping;HE Yong-ming(School of Life Science and Engineering,Foshan University,Foshan,Guangdong,528000,China)
出处
《动物医学进展》
北大核心
2018年第6期129-131,共3页
Progress In Veterinary Medicine
基金
"十二五"农村领域国家科技计划课题(2011BAD34B00)
农业部行业科技专项(201003060-09)
广东省自然科学基金(2017A030310607)
广东省省级科技计划项目(2015A040404048)
佛山市科技计划项目(佛财工[2015]143)
关键词
鸡
等效剂量
换算系数
体表面积
chicken
equivalent dose
conversion coefficient
body surface area
