摘要
目的分析尿激酶静脉溶栓治疗急性脑梗死患者不良预后的危险因素。方法回顾性分析我院180例经实施尿激酶静脉溶栓治疗的急性脑梗死患者的临床资料,探究尿激酶静脉溶栓治疗不良预后的独立危险因素。结果不良预后发生率为13.33%。Logistic回归分析结果显示,年龄>60岁、有急性脑梗死病史、有急性脑梗死家族史、合并高血压、合并糖尿病、合并高脂血症、合并冠心病、入院NIHSS评分>15分、发病至入院时间>6 h、吸烟史>3年、饮酒史>3年、有熬夜习惯均是急性脑梗死患者尿激酶静脉溶栓治疗不良预后发生的独立危险因素,而联合应用活血化瘀类中药是其保护性因素(P<0.05)。结论影响急性脑梗死患者尿激酶静脉溶栓治疗不良预后的危险因素多种多样,应积极解除危险因素,并联合应用活血化瘀类中药。
Objective To analyze the risk factors for poor prognosis of urokinase thrombolytic therapy in patients withacute cerebral infarction. Methods The clinical data of 180 patients with acute cerebral infarction treated with urokinasethrombolytic therapy in our hospital were retrospective analyzed, and the risk factors of poor prognosis in patients withacute cerebral infarction with urokinase thrombolytic therapy were analyzed. Results The incidence of poor prognosis was13.33%. Logistic regression analysis results showed that the age〉60 years old, with history of acute cerebral infarction, withfamily history of acute cerebral infarction, hypertension, diabetes, hyperlipidemia, coronary heart disease, admission NIHSSscore〉15, time of onset〉6 h, smoking history〉3 years, drinking history〉3 years and with habit of staying up late were theindependent risk factors, and the combination of medicine for activating blood circulation and eliminating stasis wasaprotective factor for poor prognosis of urokinase thrombolytic therapy in patients with acute cerebral infarcion（P〈0.05）.Conclusion There are various risk factors affecting the poor prognosis of urokinase thrombolytic therapy in patients withacute cerebral infarction. It should actively relieve the risk factors and combine with medicine for activating bloodcirculation and eliminating stasis.
作者
白文
张卓
BAI Wen;ZHANG Zhuo(Emergency Department,Traditional Chinese Medicine Hospital in Yulin,Yulin 719000;Neurology Department,Tangdu Hospital of 4th Military Medical University,Xi＇an 710032,China)
出处
《临床医学研究与实践》
2018年第18期20-21,共2页
Clinical Research and Practice
关键词
急性脑梗死
尿激酶
静脉溶栓
acute cerebral infarction
urokinase
venous thrombolysis
