摘要
目的:系统评价生血宁片治疗妊娠期缺铁性贫血的疗效,为临床提供循证参考。方法:计算机检索中国知网、万方、维普、PubMed等数据库中2008-2018年发表的关于生血宁片治疗妊娠期缺铁性贫血的临床随机对照试验(RCT),筛选文献、提取资料并采用改良后的Jadad评分量表评价纳入研究的质量,采用Stata 12.0软件进行Meta分析。结果:共纳入11项RCT,合计1 617例患者。生血宁片的总有效率均显著高于硫酸亚铁[OR=8.73,95%CI(2.96,25.69),P<0.05]、琥珀酸亚铁[OR=1.86,95%CI(1.04,3.33),P<0.05]和膳食调理[OR=3.43,95%CI(2.08,5.66),P<0.05],差异均有统计学意义。结论:生血宁片治疗妊娠期缺铁性贫血的疗效显著优于常规补铁剂。
OBJECTIVE：To evaluate therapeutic efficacy of Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy, so as to provide evidence for clinical decisions. METHODS： Retrieved from CNKI,Wanfang,VIP and PubMed,clinical randomized controlled trials（RCTs）about Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy were collected during 2008-2018. After screening literatures and extracted information, the literature quality was evaluated by using improved Jadad scale. Meta-analyses was performed by using Stata 12.0 software. RESULTS：A total of 11 RCTs were included,inulving 1 617 patients. Total response rate of Shengxuening tablets was significantly higher than those of ferrous sulfate [OR=8.73,95%CI（2.964,25.69）,P〈0.05],ferrous succinate [OR=1.86,95%CI（1.04,3.33）,P〈0.05] and dietory conditioning [OR=3.43,95% CI（2.08,5.66）,P〈0.05],with statistical significance. CONCLUSIONS：Therapeutic efficacy of Shengxuening tablets is significantly better than that of routine iron supplements in the treatment of iron-deficiency anemia during pregnancy.
作者
陈帆
刘微微
刘巧艳
曹世义
CHEN Fan1,LIU Weiwei2,LIU Qiaoyan1,CAO Shiyi1(1. School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;2. Dept. of Gynecology,HubeiProvince Maternal and Child Health Hospital,Wuhan 430070,Chin)
出处
《中国药房》
CAS
北大核心
2018年第12期1707-1710,共4页
China Pharmacy
基金
国家中医药管理局资助项目(No.国中医药科2016ZX08)
关键词
生血宁片
妊娠期缺铁性贫血
随机对照试验
META分析
Shengxuening tablets；Iron-deficiency anemia during pregnancy；Randomized controlled trial；Meta-analysis
