摘要
目的研究男性精神分裂症患者血清皮质醇和硫酸脱氢表雄酮水平(DHEA-S)与精神症状的相关性。方法研究共纳入男性精神分裂症患者120例与年龄匹配的健康自愿者110例,对患者的临床基本信息(包括发病年龄、病史、阳性和阴性症状评分及非典型抗精神药物使用情况)进行收集;对患者治疗前后血清中皮质醇、DHEA-S水平进行检测,并计算了两者之间的比值;分析皮质醇、DHEA-S水平及比值与精神症状的相关性;并与健康自愿者对应指标进行对比分析。结果治疗前患者血清中皮质醇、DHEA-S水平及比值显著高于正常对照组(P<0.01);治疗后患者血清中皮质醇、DHEA-S水平显著低于治疗前,差异有统计学意义(P<0.01),治疗前后比值差异无统计学意义(P>0.05);相关性分析发现血清中皮质醇、DHEA-S水平及比值与阴性症状评分呈正相关。结论皮质醇和DHEA-S水平紊乱可能是导致精神分裂症发病的原因,其水平可以作为疾病诊断和治疗有效性监测的生物学标志物。
Objective The purpose of this study was to examine possible associations of serum levels of cortisol and dehydroepiandrosterone-sulfate（ DHEA-S） with psychiatric symptoms in men with chronic schizophrenia. Methods This study involved 120 men with schizophrenia and 110 age-matched healthy controls,and the information of patients were collected on demographic characteristics,age at disease onset,disease duration,positive and negative syndrome scale（ PANSS） scores,and history of atypical antipsychotic treatment. Results Serum levels of cortisol and DHEA-S were calculated,as well as the ratios of the two levels. Possible correlations were explored between these levels and psychiatric symptoms before and after antipsychotic treatment. Serum levels of cortisol and DHEA-S levels as well as the ratios of cortisol to DHEA-S levels were more higher in patients than in controls（ P〈0.01）. Among patients,serum levels of cortisol and DHEA-S were significantly lower after treatment than before（ P〈0.01）,although the ratios of cortisol to DHEA-S levels remained similar. Serum levels of cortisol,DHEA-S and the ratios of the two levels were positively correlated with the negative symptoms score on the PANSS. Conclusion The pathophysiology of schizophrenia may involve in the spread levels of cortisol and DHEA-S. These levels may serve as biomarkers for diagnosing schizophrenia and monitoring treatment efficacy.
作者
彭锐
李艳
Peng Rui;Li Yan(Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Hubei 430060,China)
出处
《医学研究杂志》
2018年第6期108-111,共4页
Journal of Medical Research
