摘要
目的探讨血浆N-末端脑钠肽前体(NT-proBNP)对不同程度慢性阻塞性肺疾病(COPD)的影响。方法选取2016年1月至2017年1月我院收治的不同程度COPD患者70例,其中重度、极重度归为甲组(20例,FEV_1%<50%),轻度、中度归为乙组(50例,50%≤FEV_1%);选取同期健康体检者40例为对照组。检测并比较各组的NT-proBNP水平。结果三组的NT-proBNP水平比较,差异有统计学意义(P<0.05);甲组的NT-proBNP水平显著高于乙组及对照组(P<0.05)。甲组的FEV1%值显著低于乙组及对照组(P<0.05),乙组的FEV_1%值显著低于对照组(P<0.05)。结论慢性阻塞性肺疾病患者的血清NT-proBNP水平受FEV_1%的影响,能反映患者心功能状态及疾病严重程度,对于患者预后的评估具有一定的应用价值。
Objective To explore the effect of plasma N-terminal pro-brain natriuretic peptide （ NT- proBNP） on chronic obstructive pulmonary disease （COPD） at different degrees. Methods 70 cases of COPD patients admitted to our hospital from January 2016 to January 2017 were selected and divided into group A （20 cases of severe and extremely severe patients, FEV1% 〈 50 % ） and group B （50 cases of mild and moderate patients, 50 % ≤ FEV1%） according to the disease degree. Another 40 cases of healthy people at the same period were selected as the control group. The levels of NT-proBNP of three groups were detected and compared. Results The level of NT-proBNP showed statistical difference among three groups （P 〈0.05）, and the NT-proBNP level of group A was significantly higher than that of group B and control group （P 〈0.05）. The FEV1% value of group A was significantly lower than that of group B and control group, and the FEV1% value of group B was significantly lower than that of control group （P 〈0.05）. Conclusions The plasma NT-proBNP level of COPD patient is affected by FEV1%, suggesting that NT-proBNP can reflect the state of cardiac function and the severity of the disease, and has a certain application value for the evaluation of the prognosis of patients.
作者
潘小青
申海燕
冼伟玲
邱佩娟
PAN Xiaoqing, SHEN Haiyan, XIAN Welling, QIU Peijuan(The Sixth People＇s Hospital of Nanhai District, Foshan 528248 , China)
出处
《临床医学工程》
2018年第6期755-756,共2页
Clinical Medicine & Engineering
基金
佛山市科学技术局项目(项目编号:2015AB000692)
关键词
血浆N-末端脑钠肽前体
慢性阻塞性肺疾病
心功能
Plasma N-terminal pro-brain natriuretic peptide
Chronic obstructive pulmonary disease
Cardiac function
