摘要
目的:分析研究妊娠剧吐孕妇甲状腺功能变化。方法:随机抽取2015年2月-2016年11月90例怀孕15周的孕妇,依据其妊娠反应将其分为妊娠剧吐组(n=37)与妊娠正常组(n=53),抽取其静脉血,检测其血清游离三碘甲状腺原氨酸(FT_3)、血清游离甲状腺素(FT_4)、血清促甲状腺素水平(TSH)、甲状腺球蛋白抗体(TgAb)与甲状腺过氧化物酶抗体(TPOAb)的浓度,观察妊娠一过性甲状腺毒症和毒性弥漫性甲状腺肿(Graves)病情况。结果:经过检测发现,妊娠剧吐组孕妇的FT_3、FT_4、TgAb与TPOAb的浓度明显高于妊娠正常组孕妇,血清游离甲状腺素的浓度明显低于妊娠正常组孕妇,差异有统计学意义(P<0.05);同时妊娠剧吐组甲状腺球蛋白抗体及甲状腺过氧化物酶抗体的阳性例数多于妊娠正常组,差异有统计学意义(P<0.05);妊娠剧吐组孕妇的妊娠一过性甲状腺毒症和Graves病例数多于妊娠正常组,差异有统计学意义(P<0.05)。结论:妊娠剧吐孕妇甲状腺功能呈现出亢进变化。
Objective：To study the changes of thyroid function in pregnant women with hyperemesis grader.Method：90 cases of pregnant women with 15 weeks of gestation were randomly selected from February 2015 to November 2016.They were divided into two groups：pregnant women（n=37） and normal pregnancy group（n=53） according to their pregnancy reaction.Venous blood,the concentration of serum free triiodothyronine（FT_3）,serum free thyroxine（FT_4）,serum thyrotropin（TSH）,thyroglobulin antibody（TgAb） and thyroid peroxidase antibody（TPOAb） were measured,a transient thyrotoxicosis and toxic diffuse goiter（Graves）disease were observed.Result：The levels of FT_3,FT_4,TgAb and TPOAb in pregnant women were significantly higher than those in pregnant women with normal pregnancy,the serum free thyroxine concentration was significantly lower than that of normal pregnant women（P〈0.05）.Meanwhile,the positive rate of thyroid peroxidase antibody in pregnant women with hyperemesis gravidarum was not significantly different from that of pregnant women,here were no statistically significant（P〉0.05）.The number of pregnant thyroid poison and Graves cases in pregnant women with gestational age was higher than that in pregnant women（P〈0.05）.Conclusion：Hypothyroidism in pregnant women with hypothyroidism show hyperthyroidism.
作者
陈瑜
CHEN Yu(Zhongtang Hospital of Dongguan City,Dongguan 523220,China)
出处
《中外医学研究》
2018年第18期37-39,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
妊娠剧吐
甲状腺功能
甲状腺亢进
Hyperemesis hyperemesis
Thyroid function
Hyperthyroidism
