摘要
目的:研究莲威阿那其颗粒剂对小鼠抗炎及镇痛作用。方法:采用小鼠热板法和醋酸扭体法,检测莲威阿那其颗粒剂的镇痛作用。采用小鼠耳廓肿胀法观察莲威阿那其颗粒剂的抗炎作用。小鼠随机分为5组,即空白对照组、莲威阿那其颗粒剂高、中、低剂量组、阿司匹林组。每组小鼠连续灌胃给药7 d后,观察莲威阿那其颗粒剂的抗炎、镇痛作用。结果:莲威阿那其颗粒剂能明显抑制二甲苯所致的小鼠耳廓肿胀,中、高剂量明显提高小鼠的痛阈,对小鼠醋酸扭体法和热板法致痛反应有较好的止痛作用。结论:莲威阿那其颗粒剂有明显的抗炎、镇痛疗效。
Objective：To investigate the anti-ilnflanmmatory and analgesic effects of Lianwei Anaqi granules. Methods ：The analge sic effect of Lianwei Anaqi granules was determfined by hot plate test and acetic acid writhing test in mice. The anti-inflammator effect of Lianwei Anaqi granules was observed by ear swelling test in mice. Mice were divided into 5 groups randomly, namely blank control group, Lianwei Anaqi granules at high, mediunm and low doses groups, and Aspirin group. The anti-inflammnator and analgesic effects of Lianwei Anaqi granules were observed after every group nfiee were orally given correspondence durg （ ig for 7 days. Results ： Lianwei Anaqi granules could inhibit ear swelling caused by Xylene in nfiee markedly, and the high and medi um doses of Lianwei Anaqi granules could increase pain threshold significantly. In the acetic acid writhing test and hot plate test Lianwei Anaqi granules showed greater analgesic effects. Conclusion：Lianwei Anaqi granules have significant anti-ilfflammatory and analgesic effects.
作者
夏尔巴提.吾马尔
金小越
Xiaerbati Wumaer;Jin Xiaoyue(School of Pharmacy,Xinjiang Medical University,Urumqi 830011,China;Department of Pharmacy,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,China)
出处
《世界中医药》
CAS
2018年第5期1205-1207,1212,共4页
World Chinese Medicine
基金
新疆维吾尔自治区科技支疆项目(201191257)
关键词
莲威阿那其颗粒剂
抗炎
镇痛
小鼠
耳廓肿胀法
实验研究
Lianwei Anaqi granules
Anti-inflanmlatory
Analgesic
Mice
Ear swelling test
Experimental study
