摘要
目的探讨口腔鳞癌组织中组蛋白赖氨酸去甲基化酶4A(KDM4A)的表达变化及其与患者临床病理参数和预后的关系。方法选取110例口腔鳞癌患者的癌组织,并取其中21例患者的癌旁正常口腔黏膜组织(距离癌组织>5 cm)作为对照,免疫组化法检测样本组织中KDM4A蛋白表达。采用Kaplan-Meier生存曲线进行预后评估。分析口腔鳞癌组织中KDM4A表达与患者临床病理参数、预后的关系。结果口腔鳞癌组织中KDM4A表达水平较癌旁正常口腔黏膜组织升高(P<0.05)。口腔鳞癌组织中KDM4A表达与患者的性别、年龄、吸烟史、饮酒史和肿瘤组织分化程度均无关(P均>0.05),与TNM分期和是否发生淋巴结转移密切相关(P均<0.05)。与KDM4A表达阳性组比较,KDM4A表达阴性组患者生存率高、生存时间长(P均<0.05)。结论 KDM4A在口腔鳞癌组织中异常高表达,其与患者的TNM分期、淋巴结转移及预后有关。
Objective To explore the expression of KDM4 A in oral squamous cell carcinoma（OSCC） tissues and its correlation with clinicopathological parameters and prognosis of patients. Methods Totally 110 OSCC tissues and 21 cases of adjacent normal oral tissues（〉 5 cm from cancer tissues） from 21 patients were selected. The expression of KDM4 A protein in the sample tissues was detected by immunohistochemistry. Prognostic evaluation was performed by using the Kaplan-Meier survival curve. We analyzed the correlations of KDM4 A expression with the clinicopathological parameters and prognosis. Results The expression level of KDM4 A in the OSCC is higher than that in the normal oral mucosa（P 〈0. 05）. The expression of KDM4 A was not related to the gender,age,smoking history,drinking history,or tumor cell differentiation of patients（all P 〉 0. 05）,but was closely related to TNM stage and lymph node metastasis（both P 〈 0. 05）.KDM4 A overexpression was associated with poor overall survival（P 〈 0. 05）. Conclusion KDM4 A is abnormally highly expressed in OSCC tissues,which is associated with TNM stage,lymph node metastasis,and prognosis.
作者
何海蕾
严俊峰
王羽
刘建伟
HE Hailei;YAN Junfeng;WANG Yu;LIU Jianwei(Ganzhou People＇ s Hospital,Ganzhou 341002,China)
出处
《山东医药》
CAS
2018年第29期8-11,共4页
Shandong Medical Journal
基金
江西省卫生计生委科技计划课题(20165122)
