摘要
目的观察磷酸肌酸钠联合尼可地尔治疗急性ST段抬高型心肌梗死(STEMI)的临床疗效。方法选择医院2014年5月至2017年5月收治的STEMI患者91例,随机分为对照组(45例)和治疗组(46例)。两组患者均于行经皮冠状动脉介入(PCI)手术后给予常规治疗,对照组患者给予尼可地尔治疗,治疗组患者给予磷酸肌酸钠联合尼可地尔治疗,两组均连续治疗14 d。结果治疗组总有效率为95.65%,明显高于对照组的82.22%(χ~2=4.194,P=0.041);治疗后,两组患者心脏指数(CI)、左心室射血分数(LVEF)均增大,室壁运动积分指数(WMSI)均减小,且治疗组变化均明显优于对照组(P<0.05);治疗后,两组患者血清肌酸激酶同工酶MB(CK-MB)、心肌肌钙蛋白I(c Tn I)、基质金属蛋白酶-9(MMP-9)、脑钠肽(BNP)水平均降低,超氧化物歧化酶(SOD)水平均升高,且治疗组变化均明显优于对照组(P<0.05)。结论磷酸肌酸钠联合尼可地尔治疗STEMI的临床疗效显著,能明显减轻心功能损伤,促进心功能恢复,且安全性较好,值得临床推广。
Objective To investigate the clinical effect of creatine phosphate sodium combined with nicorandil in the treatment of patients with ST-segment elevation myocardial（ STEMI）. Methods Totally 91 patients with STEMI admitted to our hospital from May2014 to May 2017 were selected and randomly divided into the control group（ n = 45） and the treatment group（ n = 46）. The patients in the two groups were treated with conventional treatment after PCI,and then the control group was treated with nicorandil,while the treatment group were treated with creatine phosphate sodium combined with nicorandil. The two groups were treated for 14 d.Results The total effective rate of the treatment group was 95. 65%,which was significantly higher than 82. 22% of the control group（ χ~2= 4. 194,P = 0. 041）. After treatment,the cardiac indexes（ CI） and left ventricular ejection fractions（ LVEF） in the two groups were increased,and the ventricular wall motion score indexes（ WMSI） in the two groups were decreased,and the changes in the treatment group were more significant（ P〈0. 05）. After treatment,the levels of serum creatine kinase MB（ CK-MB）,cardiac troponin I（ c Tn I）,matrix metalloproteinase-9（MMP-9） and brain natriuretic peptide（ BNP） in the two groups were decreased,while the levels of superoxide dismutase（SOD） in the two groups were increased,and the changes in the treatment group were more significant（ P〈0. 05）.Conclusion Creatine phosphate sodium combined with nicorandil in the treatment of patients with STEMI has a good effect and safety,it can significantly reduce the damage of cardiac function and improve the recovery of cardiac function,which is worthy of clinical promotion.
作者
叶钜亨
高虹
童玲
李军
吴美善
Ye Juheng;Gao Hong;Tong Ling;Li Jun;Wu Meishan(Shenzhen Peole＇s Hospital,Shenzhen,Guangdong,China 518020;The Third People＇s Hospital of Shenzhen,Shenzhen,Guangdong,China 518020)
出处
《中国药业》
CAS
2018年第14期29-31,共3页
China Pharmaceuticals
基金
2015年广东省深圳市知识创新计划基础研究项目[JCYJ20150403101146303]
关键词
磷酸肌酸钠
尼可地尔
急性ST段抬高型心肌梗死
心功能
临床疗效
creatine phosphate sodium
nicorandil
ST - segment elevation myocardial
cardiac function
clinical effect
