摘要
目的:探讨前列腺液中锌离子、前列腺特异性抗原(PSA)、巨噬细胞炎性蛋白-1α(MIP-1α)与慢性非细菌性前列腺炎患者症状的相关性。方法:选取436例慢性非细菌性前列腺炎患者,其中ⅢA型291例,ⅢB型84例、Ⅳ型61例,并选同期身体健康体检者128例为正常组,收集所有被检者的前列腺液,采用湿玻片法计数前列腺液中白细胞(WBC)、卵磷脂小体(SPL)、化学比色法和酶联法测定锌离子、PSA和MIP-1α水平,采用慢性前列腺炎症状评分量表(CPSI)评估患者的前列腺炎症状,对CPSI评分与前列腺液中锌离子、PSA、MIP-1α、WBC和SPL的关系进行Pearson线性相关性分析。结果:ⅢA型组、Ⅳ型组患者前列腺液中WBC≥1+的比例高于正常组,差异具有统计学意义(P<0.05);ⅢA型组、ⅢB型组患者前列腺液中的锌离子及PSA水平低于Ⅳ型组及正常组,MIP-1α水平高于Ⅳ型组和正常组,差异具有统计学意义(P<0.05);ⅢA型组患者前列腺液中PSA水平低于ⅢB型组,MIP-1α水平高于ⅢB型组,差异具有统计学意义(P<0.05);慢性前列腺炎患者前列腺液中锌离子和PSA浓度与CPSI评分呈负相关性(P<0.05),MIP-1α与CPSI评分呈正相关性(P<0.05)。结论:前列腺液中锌离子、PSA和MIP-1α与慢性非细菌性前列腺患者症状严重程度相关,对慢性非细菌性前列腺炎的诊断和评估具有参考价值。
Objective： To investigate the relevance of zinc ion,prostate specific antigen and chemokine MIP-1α in the diagnosis of chronic nonbacterial prostatitis. Methods： 436 patients of chronic nonbacterial prostatitis were selected,including 291 III A,84 cases of III B and 61 cases of IV,and128 cases of healthy group were selected at the same time. All subjects were collected succus prostaticus,and EPS-WBC and SPL were counted by the wet slides method,and chemical colorimetric method and ELISA method were adopted to measure zinc ions,PSA and MIP-1α in prostatic fluid; adopting CPSI to evaluate patients＇ prostatitis symptoms; adopting Pearson linear relevance analysis between CPSI scores and zinc ions,PSA and MIP-1α,WBC and SPL in prostatic fluid. Results： WBC≥1 ＋proportion in prostatic fluid of III A group and IV group was higher than normal group,differences were statistically significant（ P〈0. 05）; zinc ions and PSA levels in prostatic fluid of III A group and III B group were lower than IV group and normal group,MIP-1α level was higher than IV group and normal group,differences were statistically significant（ P〈0. 05）; PSA level in prostatic fluid of III A group was lower than III B group,MIP-1α level was higher than IIII B group,differences were statistically significant（ P〈0. 05）; zinc ions and PSA concentration were negatively correlated with CPSI scores in prostatic fluid of chronic prostatitis patients（ P〈0. 05）,while MIP1α was positively correlated with CPSI scores（ P〈0. 05）. Conclusion： zinc ions,PSA and MIP-1α in prostate liquid were closely related with symptom severity of chronic nonbacterial prostate,which are valuable for the diagnosis and evaluation of chronic nonbacterial prostatitis.
作者
罗琳
牟晓兵
张瑾
LUO Lin;MOU Xiaobing;ZHANG Jin(Urinary Surgery Department of Chengdu Western Hospital,Chengdu 614000,Sichuan,China)
出处
《贵州医科大学学报》
CAS
2018年第7期802-806,共5页
Journal of Guizhou Medical University
