摘要
胃癌是我国常见的恶性肿瘤之一,其传统的治疗方式包括手术、化疗与放疗,虽然传统的治疗方式使晚期胃癌患者的生存期得到一定程度的改善,但其临床疗效仍有待提高。免疫治疗是一种新的抗肿瘤的治疗方法,旨在通过各种方法激发或增强机体自身的免疫系统,依靠自身的免疫机能控制或杀伤肿瘤细胞,其常用的方法包括过继性细胞治疗、免疫疫苗、免疫检查点的调节。近年来,胃癌的免疫治疗取得了一些成果,尤其是免疫检查点抑制剂在胃癌治疗中表现出了一定的优势。本文介绍了免疫治疗在晚期胃癌中的研究进展。
Objective Gastric cancer is one of common malignant tumors in China. The traditional treatments for gastric cancer include surgery, chemotherapy and radiotherapy. Although the survival of advanced gastric cancer patients treated with traditional treatments has been continually improved recently, many patients can not be cured. Immunotherapy is a new approach for cancer treatment, which is designed to stimulate or enhance the body＇s immune system through various methods, and then tumor cells can be controlled or killed by their own immune function. The commonly used methods include adoptive cell therapy, immune vaccine and the immune regulation of checkpoints. In recent years, some achievements have been made in immunotherapy of gastric cancer, and the immune checkpoint inhibitors have showed a certain effect in the treatment of gastric cancer. This article introduces and reviews the progress of immuno- therapy in advanced gastric cancer.
作者
杨万秋
张旭东
陈清江
YANG Wan-qiu;ZHANG Xu-dong;CHEN Qing-jiang(Xinxiang Medical College,Xinxiang 453000,China;the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《实用药物与临床》
CAS
2018年第8期845-849,共5页
Practical Pharmacy and Clinical Remedies
