摘要
目的观察地特胰岛素联合格列美脲治疗老年2型糖尿病的临床疗效。方法选择2016年1月~2017年1月我院住院治疗的80例老年糖尿病患者,随机分为观察组和对照组,每组各40例,两组患者均予糖尿病饮食,治疗前停用所有降糖药物,对照组予预混胰岛素(诺和灵30R),观察组予地特胰岛素联合格列美脲联合治疗,治疗12周后对两组的疗效及治疗前后的血糖各项指标及BMI水平进行比较分析。结果观察组患者治疗后的总有效率97.5%、对照组患者治疗后的总有效率77.5%,观察组与对照组的疗效相比,差异有统计学意义(P<0.05),观察组患者治疗后的各项血糖指标与对照组比较显著降低,差异有显著统计学意义(P<0.05),但两组患者的BMI水平治疗前后未见明显变化。治疗期间,观察组患者出现低血糖1例、对照组患者出现低血糖4例,两组低血糖的发生率分别为2.5%、10.0%,观察组患者的低血糖发生率明显低于对照组差异有统计学意义(P<0.05)。结论地特胰岛素联合格列美脲治疗老年2型糖尿病可以显著提高临床疗效,有效控制血糖、且安全性好,值得临床推广和应用。
Objective To observe the clinical effect of insulin detemir combined with glimepiride in the treatment of elderly patients with type 2 diabetes mellitus. Methods From January 2016 to January 2017, 80 cases of elderly patients with diabetes treated in our hospital were randomly divided into observation group and control group, 40 cases in each group. The patients of two groups were given diabetic diet before treatment discontinuation of all medications, the control group was treated with premixed insulin（Nuo Heling 30 R）, the observation group was given insulin detemir combined with glimepiride. The treatment effect after 12 weeks of treatment, blood glucose indicators and BMI levels before and after treatment of two groups were compared. Results After treatment, the total efficiency of the observation group（97.5%） was higher than that of the control group（77.5%）, the difference was statistically significant（P〈0.05）. The blood glucose indexes of the observation group were significantly lower than those of the control group after treatment, the difference was statistically significant（P〈0.05）. But the level of BMI before and after treatment of the two groups of patients had no obvious change. During the treatment, 1 case of hypoglycemia occurred in the observation group and 4 cases of hypoglycemia occurred in the control group. The incidence of hypoglycemia in the observation group was 2.5% and 10.0% respectively. The incidence of hypoglycemia in the observation group was significantly lower than that in the control group（P〈0.05）. Conclusion Insulin detemir combined with glimepiride in the treatment of elderly patients with type 2 diabetes can significantly improve the clinical efficacy, effective control of blood glucose, and the security is good, worthy of promotion and application.
作者
王文一
王思博
王小飞
WANG Wenyi, WANG Sibo ,WANG Xiaofei(International Centre for Diagnosis and Treatment, Tianjin First Central Hospital, Tianjin 300192, China)
出处
《中国医药科学》
2018年第15期81-83,共3页
China Medicine And Pharmacy
