摘要
目的:探讨无抽搐电休克维持治疗(M-ECT)对难治性精神分裂症患者的疗效和认知功能的影响。方法:将60例难治性精神分裂症患者随机分为两组,给予研究组药物联合为期26周的MECT,对照组仅使用药物治疗;治疗前、治疗2周、4周、13周和26周分别进行阳性与阴性症状量表(PANSS)、威斯康星卡片分类测验(WCST)、韦氏记忆测验(WMS)评定。结果:治疗后各时间点两组PANSS总分、治疗2周后的阳性症状分、治疗4周后的阴性症状分和一般病理分均较基线时明显下降(P均<0.05);研究组PANSS总分在治疗13周、26周明显低于对照组(P均<0.05);阳性症状分治疗后各时间点明显低于对照组(P均<0.05);阴性症状分和一般病理分在治疗26周明显低于对照组(P均<0.05)。治疗13周时,WCST完成分类数、WMS联想得分明显高于对照组(P均<0.05);治疗26周时,WCST错误应答数明显低于对照组;WMS再认、联想得分明显高于对照组(P均<0.05)。结论:药物联合M-ECT能快速缓解难治性精神分裂症患者的阳性症状,疗效优于单纯药物治疗,并对患者部分记忆和执行功能有改善。
Objective： To explore the effectiveness and effect of the cognitive function of maintenance electroconvulsive therapy（M-ECT） on patients with refractory schizophrenia（RSZ）. Method： Sixty RSZ patients were randomly divided into two groups： the study group was treated by both M-ECT and antipsychotic drugs for 26 weeks; while the control group was treated by drugs only. Every patient was assessed by positive and negative syndrome scale（PANSS）,Wisconsin card sorting test（WCST） and Wechsler memory scale（WMS） during the time of pre-treatment,2 weeks,4 weeks,13 weeks and 26 weeks later. Results： The total scores of PANSS of both groups at each time point after treament were decreased obviously than the ones of the baseline,and the scores of positive syndrome,during the time of 2 weeks later,negative syndrome and general psychopathology during the time of 4 weeks later were decreased obviously as well. The total scores of PANSS of the study group during the time of 13 weeks and 26 weeks later were decreased obviously than the ones of the control group（all P〈0. 05）. Compared with the control group,the scores of positive syndrome of each time point after treament of the study group were decreased obviously; the scores of negative syndrome and general psychopathology during the time of 26 weeks later were decreased obviously; the scores of categories completed in WCST and association in WMS during the time of 13 weeks later were increased obviously; the total errors in WCST during the time of 26 weeks later was decreased obviously and the scores of recognition and association in WMS were increased obviously（all P〈0. 05）. Conclusion： M-ECT combining with antipsychotic drugs on RSZ patients,which has more remarkable effect than drugs treatment only,can quickly relieve positive syndrome of patients with refractory schizophrenia and is able to improve some memory and executive functions.
作者
李桦
吴荣琴
孙复林
LI Hua;WU Rong-qin;SUN Fu-lin(Mental Health Center in Jing＇an District of Shanghai,Shanghai 200436,China)
出处
《临床精神医学杂志》
2018年第4期241-244,共4页
Journal of Clinical Psychiatry
基金
上海市静安区卫生科研课题(2013QN06)
关键词
无抽搐电休克维持治疗
难治性精神分裂症
疗效
认知功能
maintenance eleetroeonvulsive therapy （M-ECT）
refractory- schizophrenia
effectiveness
cognitive function
