摘要
目的 探讨盐酸奥洛他定联合普拉洛芬治疗老年春季角结膜炎的临床效果.方法 选取2016年8月至2017年8月本院收治的老年春季角结膜炎患者104例（208眼）,按随机对照、双盲法分为两组：对照组52例（104眼）,采取盐酸奥洛他定治疗;联合组52例（104眼）,在对照组基础上联合普拉洛芬治疗.两组均治疗14d.观察两组治疗前后临床症状改善情况,比较两组临床疗效,并详细记录其用药不良反应.结果 联合组治疗后眼红、畏光、眼异物感、眼分泌物症状评分分别为（0.98±0.39）分、（0.76±0.32）分、（1.06±0.41）分、（1.03±0.42）分,均低于对照组的（1.75±0.63）分、（1.35±0.57）分、（1.98±0.69）分、（1.82±0.65）分,组间比较差异有统计学意义（均P＜0.05）;联合组治疗后总有效率为96.16％,高于对照组的80.77％,组间比较差异有统计学意义（P＜0.05）;联合组不良反应发生率为2.91％,对照组为1.92％,组间比较差异无统计学意义（P＞0.05）.结论 盐酸奥洛他定联合普拉洛芬治疗老年春季角结膜炎患者效果显著,可缓解患者症状,且用药安全.
Objective To explore the clinical efficacy of olopatadine hydrochloride and pranoprofen for elderly patients with vernal keratoconjunctivitis.Methods 104 elderly patients with vernal keratoconjunctivitis （208 eyes） treated at our hospital from August,2016 to August,2017 were selected and randomly and doubleblindly divided into a control group and a combination group,52 cases （104 eyes） for each group.The control group were treated with olopatadine hydrochloride;in addition,the combination group were treated with pranoprofen.Both groups were treated for 14 days.The improvement of clinical symptoms in the two groups was observed before and after the treatment;the clinical effects of the two groups were compared;and the adverse drug reactions were recorded in detail.Results After the treatment,the scores of redness,photophobia,eye foreign body sensation,and eye secretion symptom were （0.98 ± 0.39）,（0.76 ± 0.32）,（1.06 ± 0.41）,and （1.03 ± 0.42） in the combination group,and were （1.75 ± 0.63）,（1.35 ± 0.57）,（1.98 ± 0.69）,and （1.82 ± 0.65） in the control group,with statistical differences （all P 〈 0.05）.The total effective rate was higher in the combination group than in the control group （96.16% vs.80.77%）,with a statistical difference （P 〈 0.05）.The incidence of adverse reactions was 2.91% in the combination group,and was 1.92% in the control group,with no statistical difference （P 〉 0.05）.Conclusions Olopatadine hydrochloride and pranoprofen for elderly patients with vernal keratoconjunctivitis is effective and safe and can alleviate their symptoms.
作者
许璨
Xu Can(Department of Ophthalmology,Shanxian Central Hospital,Heze 374300,Chin)
出处
《国际医药卫生导报》
2018年第16期2524-2527,共4页
International Medicine and Health Guidance News
关键词
老年人
春季角结膜炎
盐酸奥洛他定
普拉洛芬
The elderly
Vernal keratoconjunctivitis
Olopatadine hydrochloride
Pranoprofen
