摘要
目的 检测肾病综合征患儿血清和尿液血管生成素样蛋白3（ANGPTL3）、血管生成素样蛋白4（ANGPTL4）水平,并分析其与患儿肾功能的相关性.方法 以肾病综合征患儿和正常健康小儿为受试对象,各60例,分别记为疾病组和正常组,将疾病组分为轻度、中度和重度3个亚组.对比各组血清、尿液ANGPTL3和ANGPTL4水平,检测并对比各组肾功能指标差异,包括血肌酐（Scr）、血尿素氮（BUN）、24 h尿蛋白定量,采用Pearson相关性分析方法确定肾病综合征患儿血清、尿液ANGPTL3和ANGPTL4水平与上述肾功能指标的相关性.结果 疾病组血清ANGPTL3和ANGPTL4水平、尿液ANGPTL3和ANGPTL4水平、肾功能指标均高于正常组（均P＜0.05）,且疾病组不同病情程度患儿上述指标比较,轻度者最低、中度者次之、重度者最高（均P＜ 0.05）;疾病组患儿中,血清、尿液ANGPTL3、ANGPTL4与Scr、BUN和24 h尿蛋白定量均具有正向相关性（均r＞0,均P＜0.05）.结论 肾病综合征患儿血清和尿液ANGPTL3和ANGPTL4水平均异常升高,且与患儿的肾功能存在正向相关性.
Objective To detect serum and urine levels of angiopoietin like protein 3 （ANGPTL3） and angiopoietin like protein 4 （ANGPTL4） in children with nephrotic syndrome,and to analyze their correlation with the children＇s renal function.Methods 60 children with nephrotic syndrome were selected as a disease group,and 60 normal healthy children a normal group.The disease group was divided into a mild group,moderate group,and a severe group.The serum and urine levels of ANGPTL3 and ANGPTL4 were compared between these groups;and the differences in the renal function indicators [including serum creatinine （Scr）,blood urea nitrogen （BUN）,and 24 h urine protein quantitation] of these groups were detected and compared.The correlations of the children＇s serum and urine levels ANGPTL3 and ANGPTL4 with the above renal function indicators were determined by Pearson correlation analysis.Results The serum levels of ANGPTL3 and ANGPTL4,the urine levels of ANGPTL3 and ANGPTL4,and the renal function indicators were all higher in the disease group than in the normal group （all P 〈 0.05）,and were higher in the severe group than in the moderate group and were in the moderate group than in the mild group （all P 〈 0.05）.In the disease group,the serum and urine levels of ANGPTL3 and ANGPTL4 positively correlated with Scr,BUN,and 24 h urine protein （all r 〉 0,all P 〈 0.05）.Conclusion The serum and urine levels of ANGPTL3 and ANGPTL4 in children with nephrotic syndrome abnormally elevates;and positively correlates with their renal function indicators.
作者
祁丽美
Qi Limei(Laiyang Central Hospital,Yantai 265200,Chin)
出处
《国际医药卫生导报》
2018年第16期2530-2533,共4页
International Medicine and Health Guidance News
