摘要
聚乙二醇及其衍生物因其出色的亲水性、生物相容性、生物学惰性等特性而被广泛应用于蛋白药物修饰,其修饰可有效降低蛋白药物的免疫原性并延长体内半衰期。聚乙二醇衍生物的发展经历了第一代随机修饰,第二代特异性和功能性修饰,以及第三代分支型结构的应用。其应用也从简单的药物修饰扩展到生物传感、药物传输等方面。
Polyethylene glycol and its derivatives are widely used in protein drug modification due to the excellent hydrophilicity,biocompatibility and bioinertia.The pegylation makes it possible that protein has lower immunogenicity and longer half-life.PEG derivatives had undergone three generations,from random modifications,to site-specific and functional modifications,and then branched structures.The application of PEG derivatives also extends to biosensing and drug delivery.Advances in the development of PEG derivatives and pegylated protein drugs were reviewed in this paper.
作者
张羽
连治国
徐明波
冯芳
ZHANG Yu;LIAN Zhiguo;XU Mingbo;FENG Fang(China Pharmaceutical University;Beijing SL Pharmaceutical Co.,Ltd.Beijing 100041,China)
出处
《药学实践杂志》
CAS
2018年第4期301-306,328,共7页
Journal of Pharmaceutical Practice
