摘要
目的探讨小剂量瑞芬太尼对乳腺癌根治术老年患者的麻醉效果。方法乳腺癌根治术老年患者156例根据麻醉剂量的不同分为观察组与对照组,各78例,均给予丙泊酚复合瑞芬太尼麻醉,对照组与观察组分别采用大剂量与小剂量瑞芬太尼进行麻醉诱导,观察记录两组术后恢复效果等指标。结果观察组的术后睁眼时间、拔出喉罩时间、完全清醒时间都显著短于对照组(P<0.05),术中低血压、呼吸抑制等并发症发生率(1.3%)低于对照组(11.5%)(P<0.05)。两组T0、T1时间点的IL-2和IL-10对比无显著差异,T2时间点IL-2显著增加、IL-10显著降低(P<0.05),到T3时间点都恢复到T0水平,但组间对比无显著性差异(P>0.05)。结论小剂量瑞芬太尼在乳腺癌根治术老年患者中的应用能显著缩短术后麻醉恢复时间,减少术中并发症的发生,降低患者的全身炎性反应,值得临床推广应用。
Objective To explore the anesthetic effects of low-dose remifentanil in senile patients undergoing radical mastectomy. Methods A total of 156 senile patients undergoing radical mastectomy were divided into an observation group and a control group according to the different anesthetic doses（n =78, respectively）. Both groups were given propofol combined with remifentanil for the induction, but the doses were different, i.e., large doses and small doses of remifentanil were administered respectively. The effects in the two groups after the operation were observed and recorded. Results The eye opening time, laryngeal mask drawing time and fully awakening time in the observation group were significantly shorter than those in the control group（P〈0.05）, and the incidence of intraoperative hypotension and respiratory depression（1.3%） was lower than that of the control group（11.5%）（P〈0.05）. There was no significant difference in the comparison of IL-2 and IL-10 at the time points T0 and T1 between the two groups. At the time point T2, IL-2 increased significantly and IL-10 decreased significantly（P〈0.05）; at the time point T3, IL-2 and IL-10 were all recovered to the levels at T0, but there was no significant difference between the groups（P〉0.05）. Conclusion The application of small doses of remifentanil in the senile patients undergoing radical mastectomy can significantly shorten the postoperative recovery time, reduce the incidence of complications and the systemic inflammatory response of the patients. It is worthy of clinical application.
作者
杨菁
宁俊平
Yang Jing;Ning Junping(Department of Anesthesiology,Xi＇an XD Group Hospital,Xi＇an,Shaanxi,710077,China)
出处
《西南国防医药》
CAS
2018年第7期643-645,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
乳腺癌
瑞芬太尼
小剂量
认知功能
breast cancer
remitentanil
low dose
cognitive tunction
