摘要
目的探索1 800 MHz电磁波暴露对SD大鼠皮肤组织SOD、GSH-Px活性的影响及影响是否有"窗效应".方法将4周龄SPF级健康SD大鼠98只分为7个暴露组和7对应的对照组,暴露组分别采用0.1m W/cm2、0.3 m W/cm2、0.5 m W/cm2、0.7 m W/cm2、0.9 m W/cm2、1.0 m W/cm2、1.2 m W/cm2等7个不同功率密度的1800 MHz电磁波进行连续进行21 d,每天12 h全身暴露.暴露完成后,用酶标仪测定暴露组和对照组动物皮肤组织的SOD和GSH-PX活性.结果 0.3 m W/cm2和0.5 m W/cm2暴露组皮肤组织中SOD和GSH-Px活性均降低;其活性降低与对照组相比有统计学意义(P<0.05).0.1 m W/cm2、0.7 m W/cm2、0.9 m W/cm2、1.0 m W/cm2、1.2m W/cm2等5个暴露组对皮肤组织中GSH-Px活性和SOD活性无影响,差异均无统计学意义(P>0.05).结论实验条件下,部分功率密度的1 800 MHz电磁波暴露使大鼠皮肤组织中SOD和GSH-Px的活性降低,移动电话摸拟电磁波对SD大鼠皮肤组织氧化应激相关酶活性的影响存在"强度窗".
Objective To investigate the effect of 1 800 MHz electromagnetic radiation on activity of SOD and GSH-Px in the skin tissues of SD rats.Me thods A total of 98 healthy SD rats with SPF level,aged 4 weeks,were randomly divided into radiation group and control group.The radiation group was totally exposed under 1 800 MHz electromagnetic wave with seven different power density of radiation of 0.1 m W/cm^2,0.3 m W/cm^2,0.5 m W/cm^2,0.7 m W/cm^2, 0.9 m W/cm^2, 1.0 m W/cm^2 and 1.2 m W/cm^2 respectively.It lasted 21 days and for a period of 12 hours a day. After radiation,the activity of SOD and GSH-Px in the skin tissues were detected by enzyme marker.Re s ults In radiation group,the activity of SOD and GSH-Px in the skin tissues of SD rats were decreased under0.3 m W/cm^2 and 0.5 m W/cm^21 800 MHz electromagnetic wave. Compared with the control group, there was a significantly difference in radiation group（P〈0.05）.While under other four 1 800 MHz electromagnetic waves, the activity of GSH-Px and SOD in the skin tissues showed no statistical difference between the two groups（P〉0.05）.Under 1 m W/cm^21 800 MHz electromagnetic wave, the activity of GSH-Px showed no statistical difference between two groups（ P〉0.05）. Conclus ion The power density of 0.3 m W/cm^2 and 0.5 m W/cm^2 1 800 MHzelectromagnetic wave can reduce the activity of GSH-Px and SOD in the skin tissues of rats.
作者
木云珍
吴锡南
张嫒
林华
武惠欣
熊庆
MU Yun-zhen;WU Xi-nan;ZHANG Yuan;LIN Hua;WU Hue-xing;XING Qing(School of Public Health,Kunming Medical University,KunmingYunnan 650500;Graduate Department of Kunming Medical University,Kunming Yunnan 650500;Research Center of Kunming Medical University,Kunming Yunnan 650500;Institute of Environmental Health,Yunnan Center for Disease Control and Prevention,Kunming Yunnan 650022,China)
出处
《昆明医科大学学报》
CAS
2018年第6期22-25,共4页
Journal of Kunming Medical University
基金
云南省应用基础研究计划基金资助项目(2013FZ063)
