摘要
目的观察盐酸倍他司汀联合氟桂利嗪治疗急性眩晕症中的效果及安全性。方法选取我院2016年1月至2018年1月间收治的80例急性眩晕症患者,随机分为观察组和对照组各40例。观察组采用盐酸倍他司汀+氟桂利嗪治疗,对照组采用盐酸倍他司汀治疗。观察两组患者治疗前后的椎动脉平均血流速度(Vm)、血ET-1、CGRP水平,比较两组患者的治疗效果和不良反应情况。结果治疗后,两组的椎动脉Vm、CGRP水平均显著升高,血ET-1水平均显著降低(P均<0.05);观察组的椎动脉Vm、CGRP水平均显著高于对照组,血ET-1水平低于对照组(P均<0.05)。观察组的治疗有效率为97.50%,显著高于对照组的80.00%(P<0.05)。两组的不良反应发生率比较无统计学差异(P>0.05)。结论盐酸倍他司汀联合氟桂利嗪可有效缓解急性眩晕症患者的临床症状,且治疗安全性较高。
Objective To observe the effect and safety of betahistine hydrochloride combined with flunarizine in the treatment of acute vertigo. Methods 80 cases of patients with acute vertigo admitted to our hospital from January 2016 to January 2018 were selected and randomly divided into observation group and control group, with 40 cases in each group. The observation group was treated with betahistine hydrochloride and flunarizine, while the control group was treated with betahistine hydrochloride. The mean blood flow velocity（Vm） of vertebral artery, and levels of blood ET-1 and CGRP of two groups before and after treatment were observed. The treatment effect and adverse reactions were compared between the two groups. Results After treatment, the Vm of vertebral artery and CGRP levels of two groups increased significantly, and the blood ET-1 levels decreased significantly（all P〈0.05）. The Vm of vertebral artery and CGRP level of the observation group were significantly higher than those of the control group, and the blood ET-1 level was significantly lower than that of the control group（all P〈0.05）. The treatment effective rate of the observation group was 97.50%, significantly higher than 80.00% of the control group（P〈0.05）. No statistical difference was found in the incidence of adverse reactions between the two groups（P〈0.05）.Conclusions Betahistine hydrochloride combined with flunarizine can effectively relieve the clinical symptoms of patients with acute vertigo, with higher treatment safety.
作者
林宏浩
谢朝峰
陈锐坤
江柱
LIN Honghao;XIE Chaofeng;CHEN Ruikun;JIANG Zhu(Department of Otolaryngology,Shantou Second People＇s Hospital,Shantou 515011,China)
出处
《临床医学工程》
2018年第7期911-912,共2页
Clinical Medicine & Engineering
