摘要
目的探讨阿卡波糖联合二甲双胍治疗糖尿病合并冠心病的效果及对患者血清炎性因子和心功能的影响。方法将2015年6月~2017年6月因2型糖尿病合并冠心病于本院就诊的82例肥胖患者纳入研究并随机分组,对照组41例采用阿卡波糖治疗,观察组41例联合二甲双胍治疗,12周为一疗程,比较两组临床疗效差异。结果治疗后,观察组空腹血糖(FBG)、餐后2 h血糖等血糖指标及超敏C反应蛋白(Hs-CRP)、瘤坏死因子(TNF-α)等炎性因子水平均低于对照组,差异有统计学意义(P<0.05);治疗后观察组左室射血分数(LVEF)高于对照组,血浆脑钠肽(BNP)则更低,差异具有统计学意义(P<0.05)。结论阿卡波糖联合二甲双胍治疗糖尿病合并冠心病效果显著,可有效改善炎症反应和心功能,值得推广。
Objective To investigate the effect of acarbose combined with metformin in the treatment of diabetes mellitus complicated with coronary heart disease and its effect on serum inflammatory cytokines and cardiac function. Methods From June 2015 to June 2017 for the study and were randomly divided into 82 cases of obese patients with type 2 diabetes mellitus with coronary heart disease in our hospital, the control group of41 patients with acarbose treatment, observation of metformin treatment group of 41 cases, 12 weeks for a course of treatment, compared the clinical efficacy of two groups. Results After treatment, the observation group of fasting blood glucose（FBG）, 2 h blood glucose and postprandial glycemic index and high sensitivity C reactive protein（Hs-CRP）, tumor necrosis factor（TNF-α） and other inflammatory factor levels were lower than the control group, the difference was significant（P〈0.05）; after treatment, the left ventricular ejection fraction（LVEF） higher than the control group, plasma brain natriuretic peptide（BNP） were significantly lower（P〈0.05）. Conclusion Acarbose combined with metformin was effective in the treatment of diabetes mellitus complicated with coronary heart disease, inflammation and cardiac function improved, worthy of promotion.
作者
刘高华
Liu Gaohua(Department of internal medicine,Wuyuan people＇s Hospital of Jiangxi Province,Shangrao,Jiangxi,333200,China)
出处
《当代医学》
2018年第20期72-74,共3页
Contemporary Medicine
关键词
阿卡波糖
二甲双胍
糖尿病
冠心病
血清炎性因子
心功能
Acarbose
Metformin
Diabetes mellitus
Coronary heart disease
Serum inflammatory factor
Heart function
