摘要
目的分析我院近10年中成药不良反应(ADR)发生的特点和影响因素。方法回顾性分析我院2007—2017年中成药ADR 246例,对患者的相关资料进行总结和评价。结果其中,中药注射剂发生ADR的占比为67.5%;中成药ADR发生的年龄集中在50岁以上,发生的时间用药后6 min至1 d内,其中注射剂主要集中在6~30 min;非注射剂主要集中在1h至1d。中成药注射剂ADR主要累及患者的皮肤及附件损害(34.3%)和全身性损害(21.7%);非注射剂主要累及患者的系统-器官为胃肠系统损害(28.8%)和皮肤及附件损害(20.0%)。所有的ADR均经对症给药后得到缓解或消失,治愈率为89.4%、好转率为10.6%,无死亡和后遗症患者。结论应加强对中成药ADR的监测和管理,严格按照药品说明书用药,提高用药安全性,降低ADR对人体的损害。
Objective To analyze the characteristics and influencing factors of Chinese patent medicine adverse drug reaction（ADR） in recent 10 years. Methods A total of 246 cases with Chinese patent medicine ADR from 2007 to 2017 in our hospital were retrospectively analyzed, and the related data were summarized and evaluated. Results The incidence of ADR in Chinese patent medicine injections was 67.5%. The age of ADR occurred in Chinese patent medicine was 〉 50 years old. The time when ADR occurred in the Chinese patent medicine was concentrated within 6 min to 1 d after the drug administered, which in the injections and non-injections were 6-30 min and 1 h to 1 d respectively. The Chinese patent medicine ADR in injections mainly involved skin and attachment damage（34.3%） and systemic damage（21.7%）, which in the non-injections mainly involved gastrointestinal tract damage（28.8%） and skin and attachment damage（20.0%）. All ADRs were relieved or disappeared after treatment according to the symptoms, the cure rate was 89.4%, the improvement rate was 10.6%, and there were no death or sequela.Conclusion We should strengthen the monitoring and management of Chinese patent medicine ADR, and strictly follow the drug instructions, improve the safety of drug use and reduce the damage of ADR to the human body.
作者
仇高峰
QIU Gao-feng(the People＇s Hospital of Yongshou County, Xianyang 713400, China)
出处
《临床医学研究与实践》
2018年第19期100-101,共2页
Clinical Research and Practice
关键词
中成药
不良反应(ADR)
中药注射剂
Chinese patent medicine
adverse drug reaction（ADR）
Chinese medicine injection
