摘要
目的探究子痫前期(PE)患者的血清脑钠肽(BNP)、可溶性血管内皮生长因子受体1(sFlt-1)、一氧化氮(NO)水平及其与病情变化的相关性。方法选择2014年5月至2017年1月在该院进行产检并分娩的PE患者89例作为PE组,并选择同期在该院进行正常分娩的94例健康孕产妇(NP)作为NP组。对比分析不同严重程度、不同发病时期PE患者的血清BNP、sFlt-1、NO水平。结果 PE组患者的血清BNP、sFlt-1水平明显高于NP组,NO水平明显低于NP组,差异有统计学意义(P<0.05)。重度PE组患者的血清BNP、sFlt-1水平明显高于轻度PE组,NO水平则明显低于轻度PE组,差异均有统计学意义(P<0.05)。早发型PE组和晚发型PE组患者的血清BNP、sFlt-1水平分别显著高于早期NP组和晚期NP组,而NO水平则分别明显低于早期NP组和晚期NP组,差异均有统计学意义(P<0.05)。结论 PE发生时,孕产妇的血清BNP、sFlt-1水平异常升高,NO水平异常降低。血清BNP、sFlt-1、NO水平变化与PE病情的发展密切相关,可将其作为检测PE病情变化的参考指标。
Objective To research the correlation between the level of serum brain natriuretic peptide（BNP）,soluble vascular endothelial growth factor receptor 1（sFlt-1）and nitric oxide（NO）and the changes of condition in preeclampsia（PE）patients.Methods Totally 89 patients with PE who had prenatal examination and normal delivery in the hospital from May 2014 to January 2017 were enrolled in this study as the PE group,and 94 healthy pregnant women who underwent normal delivery during the same period were selected as the NP group.The levels of serum BNP,sFlt-1 and NO in PE patients with different severity and different onset stages were compared and analyzed.Results The levels of serum BNP and sFlt-1 in the PE group were significantly higher than those in the NP group,and the level of NO was significantly lower than that in the NP group,and the differences were statistically significant（P〈0.05）.The levels of serum BNP and sFlt-1 in the severe PE group were significantly higher than those in the mild PE group,and the level of NO was significantly lower than that in the mild PE group,and the differences were statistically significant（P〈0.05）.The levels of serum BNP and sFlt-1 in the early and late onset PE groups were significantly higher than those in the early NP group and the late NP group,while the NO levels were significantly lower than those in the early NP group and the late NP group,and the differences were statistically significant（P〈0.05）.Conclusion On the occurrence of PE,the levels of serum BNP and sFlt-1 in pregnant women elevated abnormally,and the level of NO decreased.The changes of serum BNP,sFlt-1 and NO levels are closely related to the development of PE,and can be used as a reference index to detect the changes of PE.
作者
张温
刘宏健
李宝
宋欣
韩素坤
高媛媛
ZHANG Wen;LIU Hongjian;LI Bao;SONG Xin;HAN Sukun;GAO Yuanyuan(Department of Obstetrics;Department of Emergency;Department of Nursing;Clinical Laboratory,Cangzhou People′s Hospital,Cangzhou,Hebei 061000,China)
出处
《国际检验医学杂志》
CAS
2018年第12期1473-1475,1478,共4页
International Journal of Laboratory Medicine
基金
沧州市2015年科学技术研究与发展指导计划项目(151302058)
关键词
子痫前期
脑钠肽
可溶性血管内皮生长因子受体1
一氧化氮
preeclampsia
brain natriuretic peptide
soluble vascular endothelial growth factor receptor 1
nitric oxide
