舒芬太尼和芬太尼对腹腔镜胆囊切除术患者围术期血小板活化和聚集的影响被引量：3

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摘要目的探讨舒芬太尼和芬太尼对腹腔镜胆囊切除术患者围术期血小板活化和聚集的影响。方法将32例行腹腔镜胆囊切除术患者整群随机分组法分为舒芬太尼组14例和芬太尼组18例,所有患者在术前24h(T_0)、术后24h(T_1)、术后48h(T_2)、术后72h(T_3)抽取枸橼酸钠抗凝血2ml送检。流式细胞术检测血小板糖蛋白II b/III a受体(PAC-1)、P-选择素(CD62P)、白细胞分化抗原-63(CD63)表达水平以及淋巴、单核、中性粒细胞与血小板发生聚合的百分率(LY-PLT、MO-PLT、NE-PLT)。结果舒芬太尼组在T_2、T_3时点的PAC-1和CD63阳性率低于芬太尼组,差异均有统计学意义(均P<0.05或0.01),舒芬太尼组在T_1、T_2、T_3时点的CD62P阳性率低于芬太尼组,差异均有统计学意义(P<0.05或0.01)。舒芬太尼组在T_3时点的LY-PLT和NE-PLT均低于芬太尼组,差异均有统计学意义(均P<0.05),舒芬太尼组在T_1、T_2、T_3时点的MO-PLT均低于芬太尼组,差异均有统计学意义(均P<0.01)。结论舒芬太尼对腹腔镜胆囊切除术患者围术期血小板活化和聚集有更明显抑制作用。

作者俞南南李竑斌付海青董金良周吉航

机构地区舟山医院麻醉科

出处《浙江医学》 CAS 2018年第12期1389-1391,共3页 Zhejiang Medical Journal

关键词舒芬太尼腹腔镜胆囊切除术血小板活化

分类号 R614 [医药卫生—麻醉学]

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1耿朝晖,郭竹英,胡晓波,吕立夏.血小板活化标志物:血小板与单核细胞聚合物的临床应用[J].检验医学,2011,26(6):419-421. 被引量：9

二级参考文献16

1Khosravi M. Application of the biotin-(strept) avidin system in immunochemical techniques, workshop m [ R ]. Wayne : Clinical Ligand Assay Society, 1995.
2Michelson AD, Barnard MR, Krueger LA, et al. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin:studies in baboons, human coronary intervention, and human acute myocardial infarction [ J ]. Circulation, 2001,104 ( 13 ) : 1533- 1537.
3Rinder HM, Bonan JL, RJnder CS, et al. Dynamics of leukocyte-platelet adhesion in whole blood [ J ]. Blood, 1991,78 (7) : 1730-1737.
4Ahn KC, Jun A J, Pawar P, et al. Preferential binding of platelets to monocytes over neutrophils under flow [ J ]. Biochem Biophys Res Commun,2005,329( 1 ) : 345 -355.
5Fernandes LS, Conde ID, Wayne Smith C, et al. Platelet-monocyte complex formation : effect of blocking PSGL-1 alone, and in combination withalphall b beta 3 and alpha M beta 2, in coronary stenting [J]. Thromb Res,2003,111 (3) :171-177.
6Freedman JE, Loscalzo J. Platelet-monocyte aggregates : bridging thrombosis and inflammation [ J ]. Circulation ,2002,105 ( 18 ) :2130-2132.
7Sarma J, Laah CA, Alam S, et al. Increased platelet binding to circulating monocytes in acute coronary syndromes [ J ]. Circulation, 2002, 105 ( 18 ) : 2166- 2171.
8Barnard MR, Krueger LA, Frelinger AL, et al. Whole blood analysis of leukocyte-plate|et aggregates [ J ]. Curr Protoc in Cytom, 2005,6 ( 5 ) : 151-158.
9Furman MI,Barnard MR,Krueger LA,et al. Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction [ J ]. J Am Coil Cardiol, 2001,38(4) : 1002-1006.
10Schafer A,Widder J,Eigenthaler M, et al. Increased platelet activation in young Zucker rats with impaired glucose tolerance is improved by acarbose [ J ]. Thromb Haemost,200d ,92 ( 1 ) :97-103.