摘要
目的探讨湿疹儿童患者的过敏原阳性情况,为临床提供参考依据。方法选择2016年1月至2017年12月皮肤科收治的354例湿疹儿童,分成<1岁组、1~3岁组(包括1岁但不包括3岁)、≥3岁组,采用免疫印迹法检测吸入性及食物性过敏原特异性Ig E抗体,并对检测结果进行分析。结果 354例湿疹儿童中,过敏原阳性231例(65.25%),其中119例吸入性过敏原阳性(33.62%),190例食物性过敏原阳性(53.67%),78例吸入性和食物性过敏原同时阳性(22.03%)。吸入性过敏原阳性率最高的是尘螨组合(14.69%),其次是艾蒿(12.43%)、猫毛(11.30%)和狗上皮(7.91%);食物性过敏原中主要是牛奶(36.16%)、鸡蛋白(33.33%)、牛肉(15.25%)与黄豆(9.60%)。<1岁和1~3岁组中,食物性过敏原显著高于吸入性过敏原(P<0.05)。结论儿童湿疹的过敏原以食物性过敏原为主,而吸入性过敏原随年龄增加有增多趋势。通过对湿疹儿童检测过敏原,及时针对性回避阳性过敏原,对儿童湿疹的早期诊断、干预及治疗有重要意义。
Objective To explore the allergens of children with eczema,and to provide reference for clinical practice.Methods Totally 354 children with eczema in the Department of Dermatology from January 2016 to December 2017 were divided into 1 year old group,1-3 years old group and ≥3 years old group. The specific Ig E antibody of inhalation and food allergens was detected by immunoblotting,and the results were analyzed. Results Among 354 eczema children,231 children（ 65. 25%） were positive for allergens, of which 119 were positive for inhalation allergens（33. 62%）,190 were positive for food allergens（53. 67%）,and 78 were positive for both inhalation and food allergens（ 22. 03%）. The main inhalation allergens were dust mites（ 14. 69%）, mugwort（ 12. 43%）, cat hair（11. 30%） and dog fur（7. 91%）. The main food allergens were milk（36. 16%）,egg white（33. 33%）,beef（15. 25%） and soybean（9. 60%）. In 〈1 year old group and 1-3 years old group,food allergens were significantly higher than inhalation allergens（ P〈0. 05）. Conclusion Allergens in children with eczema are mainly food allergens,and inhalation allergens increase with age. The detection of allergens and targeted avoidance of positive allergens in children with eczema is of great importance in the early diagnosis,intervention and treatment of eczema in children.
作者
郑颖
何锡跃
韩晓川
ZHENG Ying;HE Xiyue;HAN Xiaochuan(Clinical Laboratory,Shenyang Children＇ s Hospital,Shenyang 110032,China;Department of Dermatology,Shenyang Children＇ s Hospital,Shenyang 110032,China)
出处
《大连医科大学学报》
CAS
2018年第3期253-256,共4页
Journal of Dalian Medical University
关键词
湿疹
过敏原
儿童
eczema
allergen
children
