摘要
目的:探讨抗合成酶综合征肺间质患者中西医临床特点。方法:采用回顾性方法对34例抗合成酶综合征肺间质病患者的临床资料实验室指标进行分析。结果:男女之比为1∶2.09,平均患病年龄(55±12)岁。34例血清学抗体检查,12例JO-1阳性,21例Ro52阳性。14例行血气分析检查,低氧血症14例,Ⅰ型呼吸衰竭0例,Ⅱ型呼吸衰竭0例。29例患者进行肺功能检查,其中限制性通气功能障碍25例,混合性通气功能障碍0例,弥散功能障碍27例。33例有胸部高分辨CT,NSIP表现19例,NSIP+OP 7例,磨玻璃影23例,网格影23例,牵拉支气管扩张10例。中医症候学分布以痰湿、湿热出现频率较高。结论:抗合成酶综合征肺间质病中医证型以痰湿、湿热阻肺证比率最高,可见该病病理因素以痰湿、湿热为主,本病好发于女性,肺部病变症状可首发于结缔组织症状之前,并可独立进展。技工手、gottron征在本病中发病率最高,因此在发现有技工手、gottron征症状及伴有呼吸系统症状时,应早期筛查,以提高对该类疾病的认识、诊断及治疗水平。
Objective： To investigate the clinical characteristics of antisynthetase syndrome complicated with interstitial lung disease. Methods： The clinical materials and the laboratory indexes of the 34 patients of antisynthetase syndrome with interstitial lung disease were retrospectively analyzed. Results： The ratio of male to female was 1： 2. 09,the average age was（ 55 ± 12） years. In terms of serological antibody tests of the 34 patients,there were 12 positive cases of JO-1,21 positive cases of Ro52. In terms of arterial blood gas analysis of 14 patients,there were 14 cases of hypoxemia,0 case of type I respiratory failure,and 0 case of type II respiratory failure. In terms of function test of 29 patients,there were 25 cases of restrictive ventilatory impairment,0 case of mixed ventilation dysfunction,and 27 cases of diffusion impairment. In terms of 33 patients with HRCT,there were 19 cases of NSIP,7 cases of NSIP ＋ OP,23 cases of ground-glass opacity,23 cases of grid shadow,and 10 cases of bronchiolectasis. In terms of the distribution of TCM syndrome,the frequency of phlegm-dampness and dampness-heat were highest. Conclusion： The proportions of phlegm-dampness and dampness-heat were highest in antisynthetase syndrome complicated with interstitial lung disease,which shows the pathological factors of this disease are main phlegm-dampness and dampness-heat. This disease predisposes to female. The symptoms of lung appear earlier than the symptoms of the connective tissue,with its independent development. Mechanic＇s hand and gottron syndrome are the most common in the disease,so early screening should be done when patients manifest with mechanic＇s hand and gottron syndrome complicated with respiratory symptoms. Awareness of this disease,its diagnosis and treatment level should be paid more attention to.
作者
蔡永登
王玉光
焦福智
王玥
赵学慧
魏明超
CAI Yongdeng;WANG Yuguang;JIAO Fuzhi;WANG Yue;ZHAO Xuehui;WEI Mingchao(Beijing University of Chinese Medicine,Beijing 100029,China;Beijing TCM Hospital Affiliated to Capital Medical University,Beijing 100010,China)
出处
《中医药学报》
CAS
2018年第4期93-96,共4页
Acta Chinese Medicine and Pharmacology
基金
北京市医院管理局"登峰"人才培养计划(DFL20150920)
关键词
抗合成酶综合征
肺间质病
中医
病机
Anti - synthase syndrome
Interstitial lung disease
TCM
Pathogenesis
