摘要
目的分析支气管哮喘患儿血清及痰液气道重塑因子、促炎因子水平变化及其临床意义。方法选取2016年9月—2017年10月上海市奉贤区奉城医院收治的支气管哮喘患儿86例作为观察组,同期体检健康儿童86例作为对照组;根据病情严重程度将观察组患儿分为轻度组26例、中度组35例、重度组25例。比较对照组与观察组儿童、不同病情严重程度支气管哮喘患儿血清及痰液气道重塑因子、促炎因子水平。结果 (1)观察组患儿血清及痰液转化生长因子β1(TGF-β1)、骨桥蛋白(OPN)、基质金属蛋白酶9(MMP-9)水平高于对照组(P<0.05)。重度组患儿血清及痰液TGF-β1、OPN、MMP-9水平高于轻度组、中度组,中度组患儿血清及痰液TGF-β1、OPN、MMP-9水平高于轻度组(P<0.05)。(2)观察组患儿血清及痰液肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、白介素8(IL-8)水平高于对照组(P<0.05)。重度组患儿血清及痰液TNF-α、IL-6、IL-8水平高于轻度组、中度组,中度组患儿血清及痰液TNF-α、IL-6、IL-8水平高于轻度组(P<0.05)。结论支气管哮喘患儿血清及痰液气道重塑因子、促炎因子水平明显升高,且血清及痰液气道重塑因子、促炎因子水平随病情加重而升高,气道重塑、局部炎性反应在儿童支气管哮喘发生发展过程中具有重要作用。
Objective To analyze the changes and clinical significance of serum and sputum levels of airway remodeling factors and pro-inflammatory cytokines in children with bronchial asthma. Methods From September 2016 to October 2017 in Fengcheng Branch,the Ninth People＇s Hospital Affiliated to Medicine School,Shanghai Jiaotong University,a total of 86 children with bronchial asthma were selected as observation group,meanwhile a total of 86 healthy children admitted to this hospital for physical examination were selected as control group;children in observation group was divided into A group（with mild bronchial asthma,n=26）,B group（with moderate bronchial asthma,n=35）and C group（with severe bronchial asthma,n=25） according to the severity of illness. Serum and sputum levels of airway remodeling factors and pro-inflammatory cytokines were compared between control group and observation group,in A group,B group and C group. Results （1）Serum and sputum levels of TGF-β1,OPN and MMP-9 in observation group were statistically significantly higher than those in control group（P〈0.05）. Serum and sputum levels of TGF-β1,OPN and MMP-9 in C group were statistically significantly higher than those in A group and B group,meanwhile serum and sputum levels of TGF-β1,OPN and MMP-9 in B group were statistically significantly higher than those in A group（P〈0.05）.（2）Serum and sputum levels of TNF-α,IL-6 and IL-8 in observation group were statistically significantly higher than those in control group（P〈0.05）. Serum and sputum levels of TNF-α,IL-6 and IL-8 in C group were statistically significantly higher than those in A group and B group,meanwhile serum and sputum levels of TNF-α,IL-6 and IL-8 in B group were statistically significantly higher than those in A group（P〈0.05）. Conclusion Serum and sputum levels of airway remodeling factors and pro-inflammatory cytokines are significantly elevated and increase as the severity of illness aggravates in children with bronchial asthma,airway remodeling and local inflammatory stress response play important roles in the development and progression in children with bronchial asthma.
作者
王仁忠
宋斌
李恒涛
WANG Ren-zhong;SONG Bin;LI Heng-tao(Fengcheng Hospital of Shanghai Fengxian District,Shanghai 201411,China)
出处
《实用心脑肺血管病杂志》
2018年第5期39-42,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
上海市奉贤区卫生科技发展项目(20141316)
关键词
哮喘
儿童
气道重塑
痰液
促炎因子
Asthma
Child
Airway remodeling
Sputum
Pro-inflammatory cytokines
