摘要
目的:探讨厄贝沙坦治疗慢性肾功能不全的疗效及对一氧化氮的影响。方法:用比色法检测厄贝沙坦治疗前后尿一氧化氮水平。结果:慢性肾功能不全患者尿一氧化氮浓度明显下降,与尿钠、尿量呈明显的正相关,研究组的尿一氧化氮水平在厄贝沙坦治疗4周后有明显的增加。结论:尿一氧化氮水平与肾脏的功能有一定的相关性,一氧化氮在慢性肾功能不全水钠平衡的调节中发挥了重要的作用,厄贝沙坦可促进慢性肾功能不全一氧化氮合成,对肾脏有保护作用。
Objective：To investigate the effect of irbesartan on chronic renal insufficiency and its effect on nitric oxide.Methods：Urine and nitric oxide levels were measured before and after irbesartan treatment by spectrophotometry.Results：The levels of urinary NO in patients with chronic renal insufficiency decreased significantly,and there was a significant positive correlation between urinary sodium and urinary output.The urinary nitric oxide was significantly increased after irbesartan treatment for 4 weeks.Conclusions：The function of the kidney is related to the level of urinary nitric oxide.Nitric oxide plays an important role in the regulation of water sodium balance in chronic renal insufficiency.Irbesartan can promote the synthesis of chronic renal insufficiency and nitric oxide,which has a protective effect on the kidney.
作者
闫尚和
刘玉芝
丁银霞
王力刚
Yan Shanghe;Liu Yuzhi;Ding Yinxia;Wang Ligan(Huimin County People＇s Hospital of Shandong Provinee 251700;Binzhou Youfu Hospital of Shandong Provinee 2566002)
出处
《中国社区医师》
2018年第19期73-74,共2页
Chinese Community Doctors
