摘要
目的研究荧光素钠注射液不良反应的规律和特点,为临床用药提供参考。方法收集2010年1月-2017年6月我省上报的荧光素钠注射液413例,利用Excel软件进行统计并分析。结果 413例报告中男性患者略多于女性,其不良反应特征主要表现为速发型,累及系统-器官以胃肠系统损害最为常见,占总例次的58.58%,其次为皮肤及其附件损害和用药部位损害。严重不良反应累及系统-器官以全身性损害为主。过敏试验不能完全预测不良反应。结论用药过程需重视和持续关注荧光素钠注射液引起的不良反应,尤其是过敏性休克等严重不良反应。医护人员要做好用药前后不良反应的预防、监护和救治工作。
Objective To investigate the characteristics and mechanisms of adverse drug reactions（ADRs） induced by fluorescein sodium injection, so as to provide technical supports for safe and rational use of drug in clinic. Methods A total of 413 cases of fluorescein sodium injection-caused ADRs were reported in Zhejiang province from January 2010 to June 2017 and analyzed by Excel software. Results The male cases were slightly more than the females. The adverse reactions were in a rapid reactive type. System organ classes（SOCs） mainly involved in adverse reactions were gastrointestinal disorders, accounted for 58.58%, followed by skin and appendages disorders, application site disorders.Serious ADRs mainly involved the general disorders. Allergy test can not completely predict ADRs. Conclusion The adverse reactions caused by fluorescein sodium injection should be paid attention, especially the serious ADRs such as anaphylactic shock and so on. Medical staff should do well in the prevention, monitoring and treatment of ADRs.
作者
马敏康
朱勇
吕小琴
MA Min-kang;ZHU Yong;LV Xiao-qin(Zhejiang Center for ADR Monitoring,Zhejiang Hangzhou 310012,China)
出处
《中国药物警戒》
2018年第5期296-299,共4页
Chinese Journal of Pharmacovigilance
关键词
荧光素钠注射液
药品不良反应
报告
监测
fluorescein sodium injection
adverse drug reaction
reports
monitoring
