摘要
目的探讨BICE患儿脑脊液及血清中S-100b蛋白和NSE水平变化的临床价值。方法选取首次住院的36例BICE患儿为观察组,同期住院的30例轻度腹泻患儿为对照组。应用ELISA法检测两组患儿脑脊液及血清中S-100b蛋白和NSE水平。结果观察组无论急性期还是恢复期血清及脑脊液中S-100b蛋白、NSE水平均高于对照组(P<0.01),观察组急性期血清S-100b蛋白、NSE水平高于恢复期(P<0.01)。结论 BICE患儿脑脊液或血清中的S-100b蛋白和NSE水平变化能反映其脑损伤的程度,为临床治疗提供依据。
Objective To investigate the clinical value of the levels of S100 bprotein,NSE in cerebrospinal fluid and serum of patients with benign infantile convulsions associated with mild gastroenteritis.Methods 36 children patients with benign infantile convulsions associated with mild gastroenteritis who were hospitalized for the first time were selected as the observation group from October 2016 to September2017.30 children patients with mild diarrhea were hospitalized during the same period as control group.The levels of S100 bprotein and NSE in cerebrospinal fluid and serum of two groups of children were detected by ELISA.Results The levels of S100 bprotein and NSE in cerebrospinal fluid and serum of the observation group in both acute phase and convalescent phase were significantly higher than those in the control group（P 0.01）.The levels of S100 bprotein and NSE in cerebrospinal fluid and serum of the observation group in the acute phase were higher than in the recovery phase（P 0.01）.Conclusion The changes of S100 bprotein and NSE levels in cerebrospinal fluid and serum of children patients with benign infantile convulsions associated with mild gastroenteritis can reflect the degree of brain injury and provide basis for clinical treatment.
作者
徐丽云
王均林
王淑丽
李玉芬
XU Li-yun;WANG Jun-lin;WANG Shu-li;LI Yu-fen(Shandong Medical College,Linyi 276000,China;Linyi People＇ s Hospital)
出处
《山东医学高等专科学校学报》
2018年第2期81-83,共3页
Journal of Shandong Medical College
基金
临沂市科技发展计划项目(201717062)
关键词
S-100B蛋白
NSE
惊厥
腹泻
脑脊液
S100b protein
NSE
Convulsions
Gastroenteritis
Cerebrospinal fluid
