摘要
目的探讨对妊娠期子宫肌瘤红色变性患者联用沙丁胺醇与小剂量肝素钠治疗方案对妊娠结局的改善作用。方法将50例妊娠期子宫肌瘤红色变性患者作为受试者,根据PEMS3.0软件包生成的随机数表分为基础组25例,联合组25例。基础组给予硫酸镁基础治疗,联合组在前者治疗方案的基础上联用沙丁胺醇和小剂量肝素钠。对比体温恢复时间、恶露干净时间、宫缩消失时间、产后腹痛消失时间、产后月经恢复正常时间、产后肌瘤存在率,并统计母体和胎儿/新生儿不良妊娠结局发生率。结果联合组体温恢复时间、恶露干净时间、宫缩消失时间、产后腹痛消失时间、产后月经恢复正常时间均短于基础组,且联合组产后肌瘤存在率低于基础组,产后3个月内子宫肌瘤手术率低于基础组,上述指标对比差异均有统计学意义(P<0.05);联合组母体和胎儿/新生儿不良妊娠结局发生率低于基础组(P<0.05)。结论对妊娠期子宫肌瘤红色变性患者联合给予沙丁胺醇和小剂量肝素钠能够促进产后康复,降低子宫肌瘤存在率,并可显著改善母婴结局,减少母婴不良妊娠结局发生风险。
Objective To investigate the improvement effect of combined use of salbutamol and low dose heparin sodium on pregnancy outcome in patients with red degeneration of uterine fibroids during pregnancy. Methods 50 patients with red degeneration of hysteromyoma during pregnancy were selected as subjects, who were according to the random number table generated by the PEMS3.0 software package divided into basic group and combination group. The former was given Magnesium Sulfate foundation treatment, while the latter was given low dose heparin combined with salbutamol on the basis of the former. The body temperature recovery time, time of lochia, uterine disappearance time, postpartum abdominal pain disappeared time, postpartum menstrual recovery time, postpartum fibroids prevalence were compared, and the incidence rates of adverse pregnancy outcomes in maternal and fetal/neonatal were also calculated. Results The body temperature recovery time, time of lochia, uterine disappearance time, postpartum abdominal pain disappeared time, postpartum menstrual recovery time in the combination group were shorter than those in the normal group, and the incidence rate of postpartum myoma in the combination group was lower than that in the basic group, and the operation rate of uterine myoma within 3 months after delivery was lower than that of basic group, between which there were significant differences in the above indexes（P 〈 0.05）. The total maternal and fetal/neonatal adverse pregnancy outcomes in the combination group were lower than those in the basic group（P 〈 0.05）. Conclusion The combination with salbutamol and low dose heparin sodium can promote postpartum rehabilitation, reduce the incidence of uterine fibroids, can significantly improve maternal and child outcomes and reduce the risk of adverse pregnancy outcomes in pregnant women with uterine fibroids.
作者
陈远芳
CHEN Yuan-fang(Obstetrics and Gynecology Department of maternal and child health care hospital Guangshan County,Xinyang,Henan,465450,China)
出处
《临床研究》
2018年第6期68-70,共3页
Clinical Research
关键词
沙丁胺醇
小剂量肝素钠
妊娠期子宫肌瘤红色变性
母婴结局
salbutamol
Low dose heparin
red degeneration of uterine fibroids during pregnancy
maternal and neonatal outcomes
