摘要
小鼠肝炎病毒是世界范围内最常见的感染实验小鼠的病原体。小鼠肝炎病毒是一种冠状病毒,传染性强。未成年小鼠感染小鼠肝炎病毒常引起较高比例的动物死亡,成年小鼠感染小鼠肝炎病毒后多呈隐性感染,但引起一系列的免疫反应,还可引发肝炎、脑炎和肠炎等病变,从而严重影响实验结果。人们建立了多种方法检测血清中抗体或组织中病毒核酸诊断小鼠肝炎感染。小鼠种群感染小鼠肝炎病毒后可以通过重新引种或胚胎移植的方法清除病毒。
Mouse hepatitis virus（MHV） is the most common viral pathogen in contemporary lahoratory mouse colonies throughout the world. MHV belongs to the coronavirus of the mouse, is highly contagious. The majority of infections is subclinical, but still significantly influences biological responses, mainly in the field of immunology. Generally, MHV causes an acute, self-limiting infection, inapparent in adult mice. Neonates are highly susceptible to disease and show high mortality. Detection of MHV infections depends on serological screening of antibody or amplifying the nucleic acid of the genome. MHV is controlled by culling and rederivation of the affected colony using embryo transfer.
作者
陈雪婷
刘佳
CHEN Xue-ting;LIU Jia(Key Laboratory of Transgenetic Animal Research Liaoning Province,Laboratory Animal Center,China Medical University,Shenyang 110001,China)
出处
《解剖科学进展》
2018年第4期438-440,443,共4页
Progress of Anatomical Sciences
基金
国家自然科学青年基金(81301766)
辽宁省自然科学基金(2015020518)
