摘要
目的分析纳洛酮是否可改善慢阻肺呼吸衰竭患者的呼吸力学、肺功能参数以及氧代谢指标。方法用双色球分组法将2017年5月—2018年2月在该院接受治疗的66例慢阻肺呼吸衰竭患者分成对照组33例、观察组33例。其中一组单纯采取常规治疗方案(对照组),另一组在常规治疗的基础上加用纳洛酮治疗(观察组)。对比两组呼吸力学指标、肺功能参数以及氧代谢指标的变化。结果疗程结束后,观察组患者阻力[(30.26±2.12)cm H2O/(L·s)]、流量[(7.05±0.85)L/min]、平均气道压[(13.18±2.01)cm H2O]、平台压[(18.19±2.06)cm H2O]、气道峰压[(27.34±2.81)cm H2O](t=10.44、4.66、4.26、9.25、4.14,P=0.01)5项呼吸力学指标、第1秒用力呼气容积[(50.26±5.31)%]、气道阻力[(76.56±8.21)%]、响应频率[(15.65±1.28)Hz]、最大通气量[(63.65±7.54)%]、肺活量[(2.79±0.29)L](t=4.41、6.79、12.32、4.60、11.68,P=0.01)5项肺功能参数、动脉血氧[(169.51±12.04)m L/L、中心静脉血氧饱和度[(73.26±6.65)%]、血乳酸[(1.04±0.08)mmol/L]、动脉血氧分压[(59.56±4.24)mm Hg]、氧输送[(595.25±48.34)mm/(min·m2)](t=6.60、5.09、22.16、7.38、6.56,P=0.01)5项氧代谢指标都优于对照组。结论在治疗慢阻肺呼吸衰竭疾病时,应用纳洛酮能够改善患者的呼吸力学、肺功能参数以及氧代谢功能,效果令人满意。
Objective To analyze whether naloxone can improve respiratory mechanics, lung function parameters and oxygen metabolism in patients with COPD. Methods 66 patients with chronic obstructive pulmonary respiratory failure who were treated in our hospital from May 2017 to February 2018 were divided into control group（33 cases） and observation group（33 cases）. One group was treated with conventional treatment alone（control group） and the other group was treated with naloxone（observation group） on the basis of conventional treatment. The changes in respiratory mechanics, lung function parameters, and oxygen metabolism were compared between the two groups. Results At the end of the treatment period, the observation group patient resistance [（30.26±2.12）cm H2 O/（L·s）], flow rate [（7.05±0.85）L/min],mean airway pressure [（13.18±2.01）cm H2 O], platform pressure [（18.19±2.06）cm H2 O], peak airway pressure[（27.34±2.81）cm H2 O]（t=10.44, 4.66, 4.26, 9.25, 4.14, P=0.01）, five respiratory mechanics indicators, and forced expiratory volume in1 second [（50.26±5.31）%] airway resistance [（76.56±8.21）%], response frequency[（15.65±1.28）Hz], maximum ventilation [（63.65±7.54）%], lung capacity [（2.79±0.29）L ]（t=4.41, 6.79, 12.32, 4.60, 11.68, P=0.01）. Five lung function parameters, arterial oxygen [（169.51±12.04）mL/L], central venous oxygen saturation [（73.26±6.65）%], blood lactate [（1.04±0.08）mmol/L], arterial oxygen Partial pressure [（59.56±4.24）mm Hg], oxygen delivery [（595.25±48.34）mm/（min·m2）]（t =6.60, 5.09, 22.16, 7.38, 6.56, P=0.01）. Five oxygen metabolism indicators were better than the control group. Conclusion In the treatment of chronic obstructive pulmonary respiratory failure, the use of naloxone can improve the patient＇s respiratory mechanics, lung function parameters and oxygen metabolism, with satisfactory results.
作者
郑毅
刘江川
胡艳琼
胡小琴
雷均
ZHENG Yi;LIU Jiang-chuan;HU Yan-qiong;HU Xiao-qin;LEI Jun(Department of Critical Illness, Kaizhou District Hospital of Chongqing,Chongqing, 405400 China)
出处
《系统医学》
2018年第12期75-77,共3页
Systems Medicine
关键词
纳洛酮
慢阻肺
呼吸衰竭
呼吸力学
肺功能
氧代谢
Naloxone
Chronic obstructive pulmonary disease
Respiratory failure
Respiratory mechanics
Pulmonary function
Oxygen metabolism
