摘要
目的:探究肺炎支原体感染患儿免疫功能、炎症因子、红细胞沉降率(ESR)检测及临床意义。方法:选择2015年9月~2017年2月我院收治的肺炎支原体患儿122例作为观察组,同时另选120例体检健康的儿童作为对照组,比较两组免疫球蛋白、T淋巴细胞亚群、炎性因子、ESR水平差异,并分析ESR与炎性因子的相关性。结果:两组外周血T淋巴细胞水平有显著性差异(P<0.05);观察组CD3^+、CD4^+及CD4^+/CD8^+显著低于对照组(P<0.05),而CD8^+显著高于对照组(P<0.05)。观察组IgA显著低于对照组(P<0.05),IgG与对照组无显著性差异(P>0.05),IgM显著高于对照组(P<0.05)。两组超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)及ESR表达水平有显著性差异(P<0.05);观察组hs-CRP、TNF-α、IFN-γ及ESR显著高于对照组(P<0.05);支原体肺炎感染患儿的ESR与hs-CRP、TNF-α、IFN-γ水平呈显著正相关(r=0.435、0.398、0.417,P<0.05)。结论:肺炎支原体感染患儿细胞免疫、体液免疫功能较为低下,炎症反应较为剧烈,且机体炎症因子与ESR表达水平成正相关。
Objective：To explore the detection and clinical significance of immune function,inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection.Methods：A total of 122 children with Mycoplasma pneumoniae from September 2015 to February 2017 were selected as the observation group,while 120 healthy children were selected as the control group.The differences of immunoglobulin,T lymphocyte subsets,inflammatory factors and erythrocyte sedimentation rate（ESR）were compared in the two groups,and the correlation between ESR and inflammatory factors was analyzed.Results：There was a significant difference in peripheral blood T lymphocyte level between the two groups（P〈0.05）;CD3^＋,CD4^＋and CD4^＋/CD8^＋in the observation group were significantly lower than those in the control group（P〈0.05）,while CD8^＋was significantly higher in the observation group than in the control group（P〈0.05）.The IgA of the observation group was significantly lower than that of the control group（P〈0.05）,and there was no significant difference between IgG and the control group（P〉0.05）,and IgM was significantly higher than that of the control group（P〈0.05）.The two groups of hypersensitive C reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α）,interferon-γ（IFN-γ）and ESR expression level were significant differences（P〈0.05）;the hs-CRP,TNF-α,IFN-γand ESR in the observation group were significantly higher than those in the control group（P〈0.05）;the ESR of the children with mycoplasma pneumonia was positively correlated with the level of hs-CRP,TNF-αand IFN-γ,which was statistically significant（r=0.435,0.398,0.417,P〈0.05）.Conclusions：The cell immunity,humoral immune function of children with Mycoplasma pneumoniae infection are relatively low,and the inflammatory reaction is more severe,and the inflammatory factors of the body are positively related to the level of ESR expression.
作者
张玉玲
张秀霜
孟小征
张争鸣
ZHANG Yu-ling;ZHANG Xiu-shuang;MENG Xiao-zheng;ZHANG Zheng-ming(Clinical Laboratory,Beijing Huairou District Maternal and Child Health Hospital,Beijing 101400,China)
出处
《海南医学院学报》
CAS
2018年第16期1532-1534,1538,共4页
Journal of Hainan Medical University
基金
北京市科技计划课题(D1312012843312985)~~
关键词
肺炎支原体
免疫功能
炎症因子
红细胞沉降率
相关性分析
Mycoplasma pncumoniae
Immune function
Inflammatory factors
Erythrocyte sedimentation rate
Correlation analysis
