摘要
目的回顾性分析加味泻心汤联合马钱子散治疗晚期肝细胞癌的有效性和安全性。方法收集接受加味泻心汤联合马钱子散治疗的晚期肝细胞癌60例,分析无进展生存期、总生存期、肿瘤控制率评价疗效,并观察安全性。结果患者随访2年,中位无进展生存期为6.6个月,中位总生存期为11.6个月,疾病控制率38.33%(23/60),完全缓解1例(1.67%),部分缓解5例(8.33%),疾病稳定17例(28.33%),1年生存率45.00%(27/60),2年生存率38.33%(23/60),未发现明显中药相关肝肾损害等不良反应。结论加味泻心汤联合马钱子散治疗晚期肝细胞癌临床有一定疗效,未见明显不良反应。
Objective To retrospectively analyze the efficacy and safety of modified Xiexin Recipe combined with Maqianzi powder in the treatment of advanced hepatocellular carcinoma.Methods We retrospectively selected 60 patients with advanced hepatocellular carcinoma who were treated by modified Xiexin Recipe combined with Maqianzi powder.The overall survival,progression free survival,disease control rate were analyzed to evaluate efficacy.And safety was assessed by observing adverse reaction.Results The follow-up time was 2 years.Median progression free survival was 6.6 months.Median overall survival was 11.6 months.Disease control rate was 38.33%（23/60）,the complete response rate was1.67%（1 case）,partial response rate was 8.33%（5 cases）,and stable disease rate was 28.33%（17 cases）.The 1-year survival rate was 45.00%（27/60）,and the 2-year survival rate was 38.33%（23/60）.And no drug-related severe adverse reaction occurred.Conclusion Modified Xiexin Recipe combined with Maqianzi powder is effective and safe for advanced hepatocellular carcinoma.
作者
熊绍权
王莉娟
罗秋月
李亚玲
丁倩
蔡蕊
宋婷婷
吴国玉
XIONG Shao-quan;WANG Li-juan;LUO Qiu-yue;LI Ya-ling;DING Qian;CAI Rui;SONG Ting-ting;WU Guo-yu(Department of Oncology,Affiliated Hospital of Chengdu University of Traditiona/ Chinese Medicine,Chengdu（610000)
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2018年第8期936-939,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金面上项目(No.81573968)
四川省中医药管理局资助项目(No.2014A026)
关键词
泻心汤
肝细胞癌
回顾性分析
Xiexin Recipe
hepatocellular carcinoma
retrospective analysis
