摘要
目的:观察耳后注射利多卡因治疗耳鸣的临床疗效,并探讨该方法是否适合在临床推广应用。方法:将符合纳入标准的80例单侧耳鸣患者随机分为4组,在口服金纳多和甲钴胺片的基础上,分别采用不同剂量的利多卡因对患耳进行耳后注射治疗(A组2%利多卡因3ml,B组2%利多卡因2ml+生理盐水1ml,C组2%利多卡因1ml+生理盐水2ml,D组生理盐水3ml)。对比和分析治疗前后每组患者耳鸣评价量表(TEQ)评分及有效率。结果:治疗结束时4组患者的总有效率分别为80%、70%、65%和25%,治疗后1个月的总有效率分别为80%、55%、45%和0%。各组患者治疗总有效率进行χ~2检验分析,组间差异有统计学意义(P<0.05)。单因素方差分析显示,不论是治疗结束时还是治疗后1个月,4组间TEQ评分的差异有统计学意义(P<0.05),A组、B组、C组评分均明显低于D组(P<0.05),A组评分明显低于C组(P<0.05)。每组患者治疗结束时和治疗后1个月TEQ评分经配对t检验分析,B组、C组患者治疗后1个月的TEQ评分高于治疗结束时(P<0.05)。急性、亚急性、慢性耳鸣患者治疗结束时的总有效率分别为79.31%、70.83%和42.86%,治疗后1个月的总有效率分别为75.86%、45.83%和42.86%,χ~2检验结果显示,在治疗后1个月,急性耳鸣患者的总有效率明显高于亚急性和慢性耳鸣患者(P<0.05)。结论:耳后注射利多卡因对单纯主观性耳鸣有效,且利多卡因的剂量和浓度对治疗效果和疗效的持久性均有影响。耳后注射利多卡因治疗主观性耳鸣是一种值得深入研究和推广的方法。
Objective：To observe clinical efficacy of postauricular injection of lidocaine for subjective tinnitus and explore the clinical effective method in the treatment of tinnitus.Method：Eighty patients with tinnitus as their first complaint were included in our study.They were randomly divided into four groups,each with 20 cases.They were treated with oral ginaton and mecobalamin tablets,and at the same time with postauricular injection of lidocaine at different doses（Group A,2% lidocaine 3 ml;Group B,2% lidocaine 2 ml＋physiological saline 1 ml;Group C,2%lidocaine 1 ml＋physiological saline 2 ml;Group D,physiological saline 3 ml）.TEQ scores were evaluated and compared before treatment,at the end of treatment,and one month after treatment.Result：At the end of treatment,the clinical efficiency rates of four groups were 80%,70%,65% and 25% respectively.One month after treatment,the clinical efficiency rates of four groups were 80%,55%,45% and 0% respectively.There were significant differences among four groups by chi square test（P〈0.05）.Patients＇ TEQ scores of the four groups after treatment were analyzed and compared by one-way ANOVA.TEQ scores of Group A,B and C were lower than Group D（P〈0.05）.TEQ scores of Group A were lower than Group C（P〈0.05）.TEQ scores at the end of treatment and one month after treatment were analyzed by paired t-test.Group B and C had higher TEQ scores one month after treatment（P〈0.05）.The total effective rate at the end of treatment for acute,subacute and chronic tinnitus patients was 79.31%,70.83% and 42.86% respectively.The total effective rate of one month after treatment was 75.86%,45.83% and 42.86%,respectively.The results of chi square test showed that the total effective rate of acute tinnitus patients was significantly higher than that of subacute and chronic tinnitus in one month after treatment（P〈0.05）.Conclusion：Postauricular injection of lidocaine is effective for simple subjective tinnitus,and the dose and concentration of lidocaine affect the efficacy and durability.Postauricular injection of lidocaine for the treatment of subjective tinnitus is a therapeutic method worthy of further research and popularization.
作者
黄艳
傅敏
HUANGYan;FU Min(Department of Otorhinolaryngology,Guangdong General Hospital and Guangdong Academy of Medical Sciences,Guangzhou,510080,China)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2018年第15期1139-1142,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
耳鸣
利多卡因
疗效
tinnitus
lidocaine
curative effect
