摘要
目的分析慢性阻塞性肺疾病(COPD)急性加重期患者常见病毒感染的流行特点,为此病今后的预防和治疗提供科学依据。方法分析2016年4月-2017年3月住院129例COPD急性加重期患者(观察组)的临床资料,纳入同期COPD稳定期患者129例为对照组,病毒感染检测使用间接免疫荧光法检测,分析两组患者病毒感染情况,所有数据采用SPSS22.2进行分析。结果两组患者在性别、平均年龄、平均病程差异无统计学意义(P>0.05),观察组中有17例患者检出病毒感染,感染率为13.18%,对照组3例患者病毒感染,感染率为2.30%,观察组明显高于对照组,差异有统计学意义(χ2=9.118,P=0.002 5);观察组感染病毒以FLU-B最为常见,但FLU-A、FLU-B和PIV合并感染的最多,观察组FLU-A感染率显著低于对照组,差异有统计学意义(χ2=9.775,P=0.001 7);夏秋季节病毒感染率要高于春、秋季节,但差异无统计学意义(χ2=1.922,P=0.588)。结论 COPD急性加重期患者病毒感染率高于COPD稳定期,感染的病毒以FLU-B、FLU-A和PIV多见,2种或多种病毒感染现象很常见?夏秋季更易发生病毒感染,提示需重视COPD患者病毒感染的预防和治疗。
Objective To analyze the epidemiological characteristics of common viral infections in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）in order to provide a scientific basis for prevention and treatment of that disease. Methods Clinical data on 129 patients with acute exacerbation of COPD（observation group）hospitalized at this Hospital from April 2016 to March 2017 were analyzed.One hundred and twenty-nine patients with stable COPD during the same period served as the control group.A viral infection was detected using indirect immunofluorescence.Data on the two groups of patients with a viral infection were analyzed using SPSS22.2. Results The two groups did not differ significantly in terms of gender,mean age,or average duration of illness（P〉0.05）.The rate of infection in the observation group was significantly higher than that in the control group（χ2=9.118,P=0.0025）.The observation group was most often infected with influenza virus B,but combined infections with influenza virus A,influenza virus B,and a parainfluenza virus were frequent.The rate of infection with influenza virus A was significantly lower in the observation group than in the control group（χ2=9.775,P=0.0017）.The rate of infection was higher in the summer and autumn than in the spring and autumn,though not significantly so（χ2=1.922,P=0.588）. Conclusion Patients with acute exacerbation of COPD and a viral infection were most often infected with influenza virus B,influenza virus A,or a parainfluenza virus,and infection with 2 or more viruses was common.Patients were more susceptible to a viral infection in the summer and autumn,suggesting that need to pay attention to the prevention and treatment of viral infections in patients with COPD.
作者
马微
史艳霞
赵瑞芬
MA Wei;SHI Yan-xia;ZHAO Rui-fen(College of Nursing,Zhangjiakou College,Zhangjiakou 075000,Hebei,China;Respiratory Medicine,First Hospital of Zhangj iakou)
出处
《中国病原生物学杂志》
CSCD
北大核心
2018年第7期747-750,共4页
Journal of Pathogen Biology
基金
河北省科技厅基金项目(No.20122534)
关键词
阻塞性肺疾病
病毒
感染
流行特征
Obstructive pulmonary disease
virus
infection
epidemiologieal characteristics
