摘要
辛酸甲酯是一种重要的精细化工产品,具有良好的反应活性,在合成化妆品及药物中间体等诸多领域具有特殊的应用价值.而传统工艺一般采用浓硫酸为催化剂,但该工艺存在很多严重的问题,如对实验装置有很强的腐蚀性、催化剂很难回收、污染环境等,这不符合当前绿色、经济、可持续发展的大环境.而强酸性大孔阳离子交换树脂由于有高催化活性、高选择性、化学稳定性好、不腐蚀设备、无"三废"产生、易分离等优异特性,故采用了这种催化剂.通过催化剂的用量、反应原料配比、反应温度、强化反应器中的循环流量、催化剂的重复使用次数等小试条件的优化,以及在酯化过程热力学和动力学方面的探索研究,可以看出计算值与实验值几乎吻合,这对工业上合成辛酸甲酯可以起到强有力的指导作用.
As an important fine chemical products,n-caprylic acid esterification has special application value in many fields such as synthetic cosmetics and pharmaceutical intermediates due to its good reactivity.Concentrated sulfuric acid is generally used as catalyst in the traditional production process of n-caprylic acid esterification,which can result in many serious problems,such as strong corrosiveness to the experimental apparatus,difficult catalyst recovery,serious environmental pollution,etc.So that the traditional production process is not consistent with the current requirements of green,economy and sustainable development.On the contrary,the strong acid macroporouscation exchange resin is widely used as an ideal catalyst due to its many excellent properties,including high catalytic activity and selectivity,good chemical stability,non-corrosiveness to equipment,no ＂three wastes＂,and easy separation.Effects of catalyst amount,ratio of the solvent to substrate,temperature,circulating flowofthe intensified reactor andcatalyst cycles were explored to obtain a suitable reaction system.Besides,the thermodynamic and kinetic parameters of the esterification process were further calculated.It could be seem that the experimental values were almost consistent with the theoretical ones,which provided powerful guidance for the industrial applicationof n-caprylic acid esterification.
作者
刘承智
杨高东
周政
张志炳
梁银春
Liu Chengzhi;Yang Gaodong;Zhou Zheng;Zhang Zhibing;Liang Yinchun(School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,210023,China;Nantong Cellulose Fiber Company Ltd,Nontong,226008,China)
出处
《南京大学学报（自然科学版）》
CAS
CSCD
北大核心
2018年第3期612-621,共10页
Journal of Nanjing University（Natural Science）
基金
国家自然科学基金(21476105)
关键词
辛酸甲酯
条件优化
工艺研究
动力学
n-caprylic acid esterification
conditional optimization
synthesis technology
kinetics
