摘要
目的探析丁苯肽软胶囊联合依达拉奉治疗血管性痴呆的疗效和安全性。方法 90例血管性痴呆患者作为研究对象,随机分为观察组与对照组,每组45例。对照组采用依达拉奉治疗,观察组采用丁苯肽软胶囊联合依达拉奉治疗,对两组的治疗效果和治疗安全性进行比较。结果观察组患者临床治疗总有效率为93.33%,明显高于对照组的75.56%,差异具有统计学意义(P<0.05)。治疗前两组简易精神状态检查量表(MMSE)、日常生活能力(ADL)、临床痴呆程度量表(CDR)评分对比差异无统计学意义(P>0.05);治疗后,两组MMSE、ADL、CDR评分均显著优于治疗前,且观察组各项评分均明显优于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率8.89%与对照组的13.33%对比差异无统计学意义(P>0.05)。结论在血管性痴呆的临床治疗上,采用丁苯肽软胶囊联合依达拉奉进行治疗可获得理想效果,且联合用药的治疗安全性相对较高,故值得在血管性痴呆的临床治疗上进一步推广和应用。
Objective To explore the efficacy and safety of Butylphthalide Soft Capsule combined with Edaravone in the treatment of vascular dementia. Methods A total of 90 patients with vascular dementia were selected as the research objects, they were randomly divided into observation group and control group, 45 cases in each group. The control group was treated with Edaravone. The observation group was treated with Butylphthalide Soft Capsule combined with Edaravone. The therapeutic efficacy and safety of the two groups were compared. Results The total effective rate of the observation group was 93.33%, which was significantly higher than 75.56% of the control group, the difference was statistically significant（P0.05）. There were no significant differences in the Mini-Mental State Examination（MMSE）, activities of daily life（ADL） and clinical dementia rating（CDR） before treatment between the two groups（P0.05）. After treatment, the scores of MMSE, ADL and CDR in the two groups were significantly better than those before treatment, and the various scores of the observation group were significantly better than those in the control group, the differences were statistically significant（P0.05）. The incidence of adverse reactions in the observation group and the control group were 8.89% and 13.33%, there was no statistically significant difference（P0.05）. Conclusion In the clinical treatment of vascular dementia, the combination of Butylphthalide Soft Capsule and Edaravone can achieve the ideal effect, and the combination of drug treatment is relatively safe, so it is worthy of further popularization and application in the clinical treatment of vascular dementia.
作者
邹志才
邓裕朋
王少博
ZOU Zhi-cai;DENG Yu-peng;WANG Shao-bo(The People＇s Hospital of Longchuan County,Longchuan S17300,China)
出处
《中国实用医药》
2018年第22期119-120,共2页
China Practical Medicine
关键词
丁苯肽软胶囊
依达拉奉
血管性痴呆
疗效
安全性
Butylphthalide Soft Capsule
Edaravone
Vascular dementia
Efficacy
Safety
