摘要
[目的]观察应用纳洛酮（金尔伦）治疗重型颅脑损伤的临床效果。探讨其对重症颅脑损伤的疗效及机制。[方法]选择GCS3-8分患者32例为治疗组，每天应用金尔伦8.0mg，随机以29例同等伤情未用金尔伦药物治疗病例为对照组，观察意识觉醒生命体征，颅内压，头颅CT变化及远期疗效。[结果]金尔伦治疗组觉醒天数缩短；早期呼吸循环异常恢复稳定较快；伤后一周颅内压显著升高和重度脑水肿者均较对照组明显减少；伤后3个月恢复良好率明显增加；重殖及死亡率明显减少。[结论]金尔伦对重症颅脑外伤有确切的治疗效果。可以缩短昏迷时间，促进神经功能恢复，改善预后，其机制可能是拮抗或抑制损伤后阿片样物质的增多。
ObjectivesTo explore the clinical efficacy and mechanism of naloxone (NLX ) for treatment of acute severe brain injuries.Methods Sixty-one patients (GCS 3～8) were randomly divided into two groups:29 patients were treated on routine regime (Control group), whereas other 32 patients were treated by 8.0 mg NLX per day (NLX group). The consciousness, clinically vital signs, intracranial pressure, craniocerebral CT changes and neurological outcome after treatment were compared.ResultsThe time of awakening and conscious recovery in NLX group was shorter than that in control. The fluctuation of vital signs in the first 3 days, including arrhythmia circulatory and respiratory abnormality, was considerably smooth in NLX group as compared with the control. The severity of brain edema and increase of intracranial pressure within one week after trauma were also less remarkable in NLX group. More patients revived in 7 days, with higher recovery rate and lower incidence of disability in three months after trauma.ConclusionAn early successive large dosage of NLX can relieve traumatic brain edema , accelerate the recovery of coma, reduce the incidence of disability and improve the prognosis in acute severe brain injuries. The mechanism of action may be that it can antagonize or inhibit the increasing release of β-endorphine(β-EP) posttraumatically.
出处
《医学临床研究》
CAS
2002年第3期172-174,共3页
Journal of Clinical Research
