摘要
目的：评价益气升阳固齿汤联合奥硝唑治疗慢性牙周炎的疗效以及对骨保护素水平的影响。方法：选择2015年3月-2017年2月来医院治疗的慢性牙周炎患者134例，根据Excel表格随机数字表法随机分为对照组和观察组，每组67例。对照组在牙周基础治疗的基础上给予奥硝唑治疗，观察组在对照组治疗的基础上口服益气升阳固齿汤，两组均治疗4周。比较两组治疗前后牙周临床指标、龈沟液重炎性细胞因子水平、龈沟液中OPG和RANKL水平和治疗疗效。结果：研究结果显示，治疗后两组患者PD、CAL、BOP、GI和SBI水平较治疗前均显著下降，观察组治疗后PD、CAL、BOP、GI和SBI水平显著低于对照组（P〈0．05）；治疗后两组患者龈沟液中hs—CRP、IL-1β和IL-6较治疗前均显著下降，IL-10较治疗前显著提升，观察组治疗后龈沟液中hs—CRP、IL-1β和IL-6显著低于对照组，IL-10显著高于对照组（P〈0．05）；治疗后两组患者的OPG水平较治疗前显著提升，RANKL水平和RANKL／OPG值显著下降，观察组治疗后OPG水平显著高于对照组，RANKL水平和RANKL／OPG值显著低于对照组（P〈0．05）；观察组治疗有效率为94．03％，对照组治疗有效为82．09％，组间比较差异有统计学意义（P〈0．05）。结论：益气升阳固齿汤可以显著改善慢性牙周炎的临床症状，提高治疗效果，缓解牙周炎的炎性反应，增加OPG的表达，促进新骨形成，对牙槽骨的重建有较好的治疗效果。
Objective ： To evaluate the effect of Yiqi Shengyang Guchi Decoction combined with ornidazole in the treat- ment of chronic periodontitis and the effect on the levels of bone protection. Methods ： A total of 134 patients with chronic periodontitis treated in our hospital from March 2015 to February 2017 were randomly divided into the control group and the observation group according to the random number table, with 67 cases in each group. The control group on the basis of periodontal therapy was given ornidazole treatment and the observation group was treated with Yiqi Shengyang Guchi Decoction based on the treatment in control group. Two groups were treated for 4 weeks. The periodontal clinical indexes, gingival crevicular fluid, inflammatory cytokine levels, OPG and RANKL levels in gingival crevicular fluid and therapeu- tic effects were compared between the two groups before and after treatment. Results： The results showed that the PD of two groups after treatment, CAL, BOP, GI and SBI levels were significantly lower than those before treatment. The ob- servation group＇s PD, CAL, BOP, GI and SBI after treatment were significantly lower than those of the control group （P 〈 0. 05 ）. The two groups＇ hs - CRP and IL - 1 beta and IL - 6 in gingival crevicular fluid after treatment were signifi- cantly decreased, and IL - 10 significantly improved. GCF hs - CRP, IL - 1 beta and IL -6 after treatment in observa- tion group were significantly lower than those of the control group, and IL - 10 was significantly higher than that of the control group（P 〈0. 05）. Two groups＇ OPG level after treatment was significantly improved, and the level of RANKL and the RANKL/OPG value decreased significantly after treatment in the observation group. The level of OPG was signifi- cantly higher than that of the control group and the levels of RANKL and RANKL/OPG were significantly lower than those of the control group（ P 〈 0.05 ）. The effective rate of treatment group was 94.03%, and that of the control group was 82. 09%. The difference between the two groups was significant（P 〈 O. 05 ）. Conclusion： Yiqi Shengyang Guchi Decoction can significantly relieve the symptoms of chronic periodontitis, improve the treatment effect, relieve the inflammatory re- action of periodontitis, increase the expression of OPG, and promote the formation of new bone and reconstruction of alve- olar bone, with good treatment effect.
作者
王杨洋
霍峰
赵婵媛
张海龙
王美艳
WANG Yangyang;ZHAO Chanyuan;ZHANG Hailong;WANG Meiyan;HUO Feng(Department of Oral Surgery,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Department of Orthodontics,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Department of Stomatology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China;Department of Stomatology,Chengde Nursing Vocational College,Chengde 067000,Hebei,China)
出处
《中华中医药学刊》
CAS
北大核心
2018年第8期2012-2015,共4页
Chinese Archives of Traditional Chinese Medicine
基金
承德市科技支撑计划项目(201701A060)
关键词
益气升阳固齿汤
慢性牙周炎
骨保护素
疗效
Yiqi Shengyang Guchi Decoction
chronic periodontitis
osteoprotegerin
curative effect
